(E) RT-PCR on RNA from spleen tissue of IL-23R, IL-23R-Y416F and IL-23R-Y416FΔICD mice. GAPDH served as control. (F) IL-23R cell surface expression of spleen cells from IL-23R (light gray), IL-23R-Y416F (black) and IL-23R-Y416FΔICD (dark gray) mice 5 days after ...
This suggests that B cells are not a uniform population of cells. B cells are responsible for adaptive immunity; they secrete immunoglobulins that bind to unprocessed antigens. B2 lymphocytes are the most abundant B cells in spleen and lymphoid organs. They produce IgG, which is antigen-specific...