johnsonii produced abundant indole-3-lactic acid (ILA) leading to the activation of aryl hydrocarbon receptor (AhR) responsible for the mitigation of colitis. Interestingly, L. johnsonii cannot utilize BG but requires a cross-feeding with Bacteroides uniformis, which degrades BG and produces ...
infantis grown on HMO produced significantly greater quantities of the tryptophan metabolite indole-3-lactic acid (ILA). Significantly higher amounts of ILA were also found in fecal samples from a population of infants with high compared to low abundance of Bifidobacterium species. The direct effects...
the effect of BG on the gut microbiota was characterized by an increased abundance ofL. johnsonii. Colonization ofL. johnsoniialleviates colitis by activation of the AhR–IL-22 signaling pathway. We also proved thatL. johnsonii
Finally, this study emphasizes the antidepressant efficacy of psychobiotic-derived ILA, potentially mediated by aryl hydrocarbon receptor (AhR) signaling activation to alleviate neuroinflammation. This study unveils the molecular and genetic foundations of psychobiotics' antidepressant effects, offering insights...
Our previous studies have shown that Lactiplantibacillus plantarum DPUL-S164-derived indole-3-lactic acid (ILA) ameliorates intestinal epithelial cell barrier injury by activating aryl hydrocarbon receptor (AhR) and nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathways and promoting ti...
found that lemon exosome-like nanoparticles combined with Lacticaseibacillus rhamnosus GG (LGG, ATCC 53103) and Streptococcus thermophilus ST-21 can enhance the production of ILA, IAld, the active aryl hydrocarbon receptor (AhR) signaling pathway and enhance interleukin–22 (IL–22) secretion, ...