preparation of labeledindole-3-acetic acidand substituted indole-3-acetic acids is fromphenylhydrazineor halogen substitutedphenylhydrazines(Baldi, Slovin, & Cohen, 1985) using [13C5]2-oxoglutaric acid ([13C5]α-ketoglutarate). This method can label the five-member ring, the side chain, or ...
in the naphthyl ring to any extent. legco.gov.hk legco.gov.hk 任何在結構上可從 3-(1-萘甲酰基)吲哚或 1-H-吲哚-3 基-1-萘甲烷通過在吲哚環之氮原子上以烷基、鏈烯基、環烷甲基、環烷乙基或2-(4-嗎啉基) 乙基取代所生成之化合物(該化合物現時不包括在《危險藥物條例》 (第 134 章)附表 1...
Gomez-Monterrey, IMCampiglia, PBertamino, AAquino, CMazzoni, ODiurno, MVIacovino, RSaviano, MSala, MNovellino, EGrieco, PEuropean journal of organic chemistrySynthesis of Novel Indole-BasedRing Systems by Acid-Catalysed Condensation from α-Amino Aldehydes andL-Trp-OMe. Gomez Monterrey I M,...
halogen, nitro, amino, loweralkyl, loweralkoxy or hydroxy; Y is hydrogen, loweralkyl, loweralkoxy, arylloweralkoxy, hydroxy, halogen, nitro or amino; the pharmaceutically acceptable acid addition salts thereof, and, where applicable, the geometric and optical isomers and racemic mixtures thereof. ...
Indole was also used in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings. The participation of the nitrogen lone electron pair in the aromatic ring means that indole is not a base, and it does...
the amino group, and the indole ring, with a further interaction between the carbonyl oxygen and the neighbouring CH group on thepyrrole ring<2001PCP1819>. Resonant ion-dip IR spectroscopy of each of seven conformational isomers of tryptamine has shown that conformers possess unique spectral signat...
Melatonin (MLT) is a hormone produced in the brain by the pineal gland, from the amino acid tryptophan. It is also an antioxidant hormone with a particular role in the protection of nuclear and mitochondrial DNA. In recent years, many physiological properties of MLT have been described resultin...
It has a bicyclic structure, consisting of a six-membered benzene ring fused to a five-membered nitrogen-containing pyrrole ring. It can be produced by bacteria as a degradation product of the amino acid tryptophan. It occurs naturally in human feces and has an intense fecal smell. This off...
Gomez-Monterrey IM, Campiglia P, Bertamino A, Aquino C, Mazzoni O, Diurno MV, Iacovino R, Saviano M, Sala M, Novellino E, Grieco P (2008) Synthesis of novel indole-based ring systems by acid-catalysed condensation from α-amino aldehydes and L-Trp-OMe. Eur J Org Chem 1983–1992...
theindoleringisprobablyoneofthemostimportantstructuresindrugdiscovery,4aswellasoneoftheheterocyclicsystemsmorecommonlyfoundinnaturalproducts.5Therefore,anymethodaimedatthepreparationofinnovativeindolederivativesisofinvaluableinterestinmedicinalchemistry.Inasimilarmanner,thetetramicacidisachallengingstructurethatispresentinahigh...