Lindel, T.; Marsch, N.; Adla, S.K. Indole prenylation in alkaloid synthesis. In Alkaloid Synthesis; Springer: Berlin, Germany, 2011; pp. 67-129.Lindel T, Marsch N, Adla S K. Top Curr Chem. 2012; 309 :67–130. doi: 10.1007/128_2011_204. [ Cross Ref ]Lindel, T., Marsch, ...
In addition to indole molecules, there were mono-indole-, di-indole-, vinblastine-, vimblastine-, gelsedine-, geissospermidine-, koumine-, geissospermidine-, iboga-, perakine-, corynanthe-, vincamine-, ajmaline-, aspidorpema-, strychnos-type, β-carboline alkaloids and indole alkaloid ...
Prenylation is a ubiquitous process common to almost all living organisms, and a key transformation in organic synthesis. Dearomative prenylation reactions of tryptophan derivatives lead to various prenylated indoline alkaloids with diverse biological activities. However, enantioselective dearomative prenylations...
This family broadly includes the hapalindoles, welwitindolinones, fisherindoles and ambiguines amongst others, all of which have an isonitrile- or isothiocyanate-containing indole alkaloid skeleton, with a cyclized isoprene unit. The hapalindoles are diversified into the welwitindolinones, fischerindo...
can be successfully accessed in high yield with excellent regio- and stereo-selectivity. This transformation can also tolerate a wide range of functional groups and achieve good efficiency in large-scale synthesis under oxidant-free conditions. In addition, cyclic voltammetry, electron paramagnetic resona...
Protein prenylation Jasmonate Catharanthus roseus Alkaloid Type I protein geranylgeranyltransferase Access this article Log in via an institution Buy article PDF 39,95 € Price includes VAT (China (P.R.)) Instant access to the full article PDF. Rent this article via DeepDyve Institutional sub...
With gram scale access to hapalindole U, the first total synthesis of an ambiguine alkaloid, namely (+)-ambiguine H was completed. This work was made possible through several recently discovered and powerful methodologies including: (I) The first example of an oxidative coupling of a ketone ...
With gram scale access to hapalindole U, the first total synthesis of an ambiguine alkaloid, namely (+)-ambiguine H was completed. This work was made possible through several recently discovered and powerful methodologies including: (I) The first example of an oxidative coupling of a ketone ...
Here, we report complete elucidation of the malbrancheamide biosynthetic pathway accomplished through complementary approaches. These include a biomimetic total synthesis to access the natural alkaloid and biosynthetic intermediates in racemic form and in vitro enzymatic reconstitution to provide access to ...
Step-economic synthesis of (±)-debromoflustramine A using indole C3 activation strategyFlustra foliaceaAlkaloidNCS-mediated activationC3 reverse prenylationA concise and practical strategy to obtain C3 reverse-prenylated pyrrolidinoindoline scaffold has been executed in 28.8% overall yield. The key ...