Amides or esters of 3-indole acrylic acids may be obtained by reacting glyoxal compounds with phosphonium alkenes. Compounds in which R 5 is a substituent joined to the indole ring via a nitrogen atom may be obtained by transforming the corresponding nitro compound, the transformation being ...
However, geometric selectivity gives barriers to the large-scale yield of β-branched-α-amino acids. To solve the problem, Y. Sawai et al. managed to synthesize β-methyltryptophan ethyl ester (β-MeTrp-OEt) under facile conditions, making large-scale preparation of N-[(1R,2S)-1-({5-...
摘要: Neither β-3-indoleacrylic acid nor α-oximino-β-3-indolepropionic acid (synthetic products related in chemical structure to aminoacids) could replace tryptophane for purposes of growth under the experimental conditions employed.-J. S. Thomson.关键词:...
A novel one-pot two-step multi component reaction of acrylic aldehydes, bromoanilines, acids and isocyanides yielding polysubstituted indoles is described... Cédric,Kalinski,and,... - 《Tetrahedron Letters》 被引量: 91发表: 2006年 Synthesis of the Erythrinan Skeleton by Acid-Promoted Cyclization...
[8]. Certain metabolites such as short-chain fatty acids (SCFAs), bile acids, and indole derivatives were found significantly changed in patients with IBD, which affect intestinal homeostasis via multiple mechanisms [9]. Among them, many indole derivatives have been reported to modulate intestinal ...
Joshi S, Ghosh I, Pokhrel S, Mädler L, Nau WM (2012) Interactions of amino acids and polypeptides with metal oxide nanoparticles probed by fluorescent indicator adsorption and displacement. ACS Nano 6:5668–5679 CAS PubMed Google Scholar Kamnev AA, Tugarova AV, Antonyuk LP, Tarantilis ...
It is also possible to adjust the pH with alkalinizing agents chosen, in particular, from amines such as alkanolamines, alkylamines and alkali metal or ammonium hydroxides or carbonates, in particular when the precursors are used in the form of salts of strong acids. ...
FFA (free fatty acids) were then added to the cells at the indicated concentrations (300 μM) for the indicated times (3 h). 10 min before the end of the FFA treatment, the cells were stimulated with insulin (20 nM)/melatonin (10 nM)/test compounds (10 nM) at 37° C. 2-[3H]...
In addition, fatty acids such as oleic acid find use in the preparation of injectables. Compounds of formula I may also be administered in the form of suppositories for rectal administration of the drug. These compositions can be prepared by mixing the drug with a suitable non-irritating ...
CheminformTamam GH, Soliman EA, El-Gendy AM, Al-Kady AY (1987) Alkylation of indole with β-aroylacrylic acids and some studies on the alkylated products. J Chem Soc Pak 9:1-10Tamam GH, Soliman EA, El-Gendy AM, Al-Kady AY (1987) Alkylation of indole with \(\beta \) -aroyl...