Indole - 3 -glycerol phosphate synthase (IGPS) plays an important role in the survival of Mycobacterium tuberculosis. The trpC gene, encoding IGPS, is essential for the growth of M. tuberculosis. It was expressed at the transcriptional level in cultured M. tuberculosis. The recombinant IGPS with...
The next step is the formation of the indole moiety, which is catalyzed by indole-3-glycerol phosphate synthase (IGPS; the product of trpC). This reaction comprises a ring closure of the substrate 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) into the product indole-3-glycerol...
synthetase of tryptophan biosynthesis from three species of Enterobacteriaceae - McQuade, Creighton - 1970 () Citation Context ...on of AS-PRT is catalyzed by the product of trpC, PR-anthranilate isomerase (PR-AnI), EC 5.3.1.24, and indole3-glycerol-phosphate synthase (IGPS), EC 4.1.1.48....
Studies have suggested that the enzyme indole‐3‐glycerol phosphate synthase (IGPS) in M. tuberculosis(MtIGPS) coded for by the trpC gene could be a target (Shen et al. 2009). The interactions between ligands and MtIGPS were thus investigated by introducing m...
(GGPP), which condenses with indole 3-glycerol phosphate to form 3-geranylgeranylindole (GG-I) in the presence of JanC, followed by epoxidation and cyclisation steps catalyzed by JanM and JanB, to form paspaline. JanP is proposed to catalyse the conversion of paspapline to 13-desoxypaspa...