atherosclerosismetabolismpatientsDearEditor,Indole-3-carboxaldehyde(ICA)is a gut microbe-derived tryptophan metabolite.Here,we explored the role of ICA in atherosclerosis.Plasma tryptophan metabolites were measured in healthy individuals and patients with atherosclerosis(Supplementary Table S1).The latter group...
It has been suggested that tryptophan was converted to ICA via IAA in microorganisms [43]. Several holoparasitic dicotyledonous plants, however, can directly metabolise L-tryptophan to indole-3-carboxaldehyde, which is further converted to ICA [44]. The ICA biosynthetic pathway in ME4-2 was ...
The active principle responsible for antibiofilm activity was identified as indole-3-carboxaldehyde (ICA) after bioassay guided purification and gas chromatography-mass spectrometry analysis. Further, in vitro antibiofilm activity of ICA was confirmed through light microscopy, confocal imaging, scanning ...
Indole-3-carboxaldehydeConformational analysisFT-IRFT-RamanDensity functional theoryFMOsNBOBioactivityThe potential energy surface (PES) scan was performed for indole-3-carboxaldehyde (ICA) and the most stable optimized conformer was predicted using DFT/B3LYP method with 6-31G basis set. The ...
Platinum and copper complexesCrystal structureInfrared and Raman spectraDensity functional theoryIn vitro antiproliferative activityPt(II) and Cu(II) complexes, trans-[PtCl2(7AI3CAH)(2)] and [CuBr2(7AI3CAH)(2)](n), containing 7-azaindole-3-carboxaldehyde (7AI3CAH) have been synthesized and ...
Pt(II) and Cu(II) complexes, trans -[PtCl2(7AI3CAH)2] and [CuBr2(7AI3CAH)2]n, containing 7-azaindole-3-carboxaldehyde (7AI3CAH) have been synthesized and investigated by a single crystal X-ray diffraction, vibrational spectroscopy and DFT calculations. In the platinum(II) complex two ...