The age at onset of motor symptoms in Huntington's disease (HD) is driven byHTTCAG repeat length but modified by other genes. In this study, we used exome sequencing of 683 patients with HD with extremes of onset or phenotype relative to CAG length to identify rare variants associated ...
Mobility and balance problems are common and often debilitating features of Huntington's disease (HD). In this exploratory study we aimed to investigate the influence of disease severity, severity of motor deficits, lower limb muscle strength, cognition, executive function, lean muscle mass and react...
Evidence from small-scale studies indicates that impairments in postural stability are an early and disabling feature of Huntington's disease (HD) and may be a useful clinical endpoint for disease modifying trials. Larger studies are needed to confirm these preliminary findings and the suitability of...
Huntington's disease (HD) is a hereditary neurodegenerative disease in which balance and gait impairments inevitably develop, placing individuals at high risk for injurious falls and lowering their quality of life. In a study designed to examine the efficacy of an exercise program using the video ...
Miner,Nicholas Migliore,Jane S. Paulsen 展开 摘要: Purpose The reliability and construct validity of the 12-item World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0) were examined in individuals with Huntington disease (HD). Methods We examined factor structure (confirmatory factor...
P oster 4: The Effect of Video Game-Based Exercise on Dynamic Balance and Mobility in Individuals with Huntington's Disease Journal of Neurol- ogy, Neurosurgery & Psychiatry. 2010;81(Suppl 1):A40-A40.Kegelmeyer, D., et al., J04 The effect of video game-based exercise on dynamic ...
The aim of the present study was to quantify explosive joint torque or the ability to develop joint torque rapidly, typically measured as the rate of torque development, in individuals with prodromal Huntington's disease and healthy controls and its associations with measures of disease burden and ...
and the patient usually dies within 15 years of diagnosis. Approximately 1 in 25,000 Caucasians have this disease. Huntington's disease has not been associated with any other disease, now or in the past. Why might natural selection not have eliminated such a deleterious allele from the ...
摘要: The reliability and construct validity of the 12-item World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0) were examined in individuals with Huntington disease (HD).关键词: Neuropsychology Neuropsychological assessment World Health Organization Disability Assessment Schedule 2.0 (...
Motor-cognitive dual-task deficits in individuals with early-mid stage Huntington disease Quinn, "Motor-cognitive dual-task deficits in individuals with early-mid stage Huntington disease," Gait & Posture, vol. 49, pp. 283-289, 2016... NE Fritz,K Hamana,M Kelson,... - 《Gait & Posture》...