These data suggest that haloperidol and pimozide act on the striatal cholinergic neurons through strong blockade of dopamine receptors. Reserpine presumably decreased striatal acetylcholine levels indirectly by depleting biogenic amines. Clozapine and 1-fenfluramine were unable to block the action of ...
The rapid progress in the area of molecular biology has provided us with the primary structures of a large variety of receptor proteins, many of which belong to the G-protein coupled receptor super family (e.g., dopamine (DA) D1and D2receptors, serotonin (5-HT) 5-HT1A, 5-HT1Cand 5-...
(Carlsson1988; Goff and Coyle2001; Javitt2004). It may also offer a theoretical frame for the use of D3antagonists in the treatment of schizophrenia, as a therapeutic alternative to direct glutamatergic antipsychotic drugs, such as agonists or positive modulators of the metabotropic glutamate ...