B) Northern analysis of NOGO/RTN4. NOGO-A specific probe identified two NOGO-A isoforms (A1, A2). Both isoforms increased with developmental age, the shorter form at slightly greater expression levels overall. A NOGO probe common to all isoforms (A, B, & C) confirmed progressive NOGO-A ...
This disorder is due to the genetic defect of uroporphyrinogen III cosynthase. This defect results in the accumulation of high amounts of uroporphyrin I in all tissues, leading to clinical manifestations ranging from mild to severe chronic damage of the skin, cartilage and bone. Hypertrichosis,...