Irritable bowel syndrome (IBS) is one of the most prevalent disorders of gut-brain interaction with a population lifetime risk of 11% [1] and a point prevalence of 4.1% according to the strict Rome IV criteria [2]. IBS research is extremely challenging due to the multifactorial etiology of...
We present measurement-device-independent quantum secret sharing (QSS) and quantum conference (QC) schemes based on continuous variable (CV) four-mode cluster state with different structures. The users of the protocol prepare their own Einstein-Podolsky-Rosen (EPR) states, respectively. One mode of...
For the purity-independent network construction, patient cohorts with both pancreatic cancer and normal adjacent samples were included. Samples other than those identified as outliers during quality control checking were included for regulation prediction, obtained from TCGA datasets and four pathological pan...
However, molecular, cellular and clinical responses to BETi treatment are highly variable, presumably due to the high degree of genetic and biological heterogeneity found even within one single subtype of these patholo- gies. In addition, BETi have been shown to be associated with a high level ...
2 1 1 0 3 4 2 6 3 Total 03 05 01 16 08 04 3 10 Table 3 Cox regression analysis for overall survival of tongue cancer patients Univariate survival analysis Variable Age, years o60 X60 Hazard ratio 1.00 1.84 95% CI 0.96 – 3.45 P-value 0.056 Gender Male Female 1.00 0.97 0.52 – ...
Co-stimulation with CCK (1 nM) and CCK-JMV at variable concentrations led to a dose-dependent inhibition of CCK-mediated PKD1 S916 and S744/748 phosphorylation by CCK-JMV. After co-stimulation with CCK (1 nM) and maximal CCK-JMV concentrations (10 μM), phosphorylation of both S916 and...
To further test the strength of the immune clusters as an important prognostic biomarker, we used a stepwise backward selection. From the initial Cox models containing all variables, we removed the weakest predictor variable only if this did not weaken the model (as monitored by the calculation ...
The estimated prognostic value of each variable in relation to overall survival among the 86 patients studied is expressed as a P value. We used COX-2 expression as well as the other prognostic markers of ovarian carcinomas that were significant in univariate analysis. The variables used in Cox...
Microglia are central players in brain innate immunity and have been the subject of extensive research in Alzheimer’s disease (AD). In this review, we aim to summarize the genetic and functional discoveries that have advanced our understanding of microg
However, symbiosis-related phenotypes, such as the spatial structure of bacteriocytes and the physiological adaptations between the host and the symbiont, are highly variable in bivalves [25]. The evolutionary fingerprints under these variations need further investigation. Symbiont digestion through ...