Esters 4 and 5 were reduced in ethanol with hydrogen gas on Pd/C catalyst. Resulting amines 6 and 7 were azocoupled (NaNO22/TsOH ) with phenol in water/MeCN mixture (setup similar to black quencher synthesis described in [28]) to yield target compounds 4-aphin and 6-aphin. Figure 2...
P261 - Avoid breathing dust/fume/gas/mist/vapours/spray.P264 - Wash skin thouroughly after handling.P270 - Do not eat, drink or smoke when using this product.P280 - Wear protective gloves/protective clothing/eye protection/face protection.P301 + P312 - IF SWALLOWED: call a POISON CENTER ...