Leptin at low doses (0.1-30 µg/kg) decreased resting heart rate; at high doses (150-300 µg/kg), leptin induced a biphasic effect (decrease and then increase) on heart rate. In the presence of high-dose propranolol (30 mg/kg), high-dose leptin only reduced heart rate and ...
Background Current guidelines recommend medications with rate control properties for symptomatic patients with hypertrophic cardiomyopathy (HCM) based on the rationale that lowering heart rate (HR) improves their symptoms. Whether sleep disordered breathing (SDB) is associated with increased HR in HCM ...
Results: A gradual increase in heart rate was observed before an SB event, and B1, A1, A2, and A3 were significantly higher than B10 (P < .01). The threshold value was set at 110% when the mean of all heart rates of the second night of recording was set at 100%. A total of ...
left ventricular interior dimension at diastole.N=5 (CTRL) and 7 (OE). (f) Survival rate of nine CTRL and eight OE mice over time. (g) Manifestation of theCOUP-TFIIgene signature in human heart samples (GSE1869).COUP-TFIIgene signature is curated from all COUP-TFII downstream targets ...
A longitudinal analysis of COVID-19 lockdown stringency on sleep and resting heart rate measures across 20 countries Article Open access 13 July 2021 Introduction The ongoing COVID-19 pandemic has had wide-ranging effects on sleep health around the world. These effects include changes in sleep ...
Ferroptosis is an iron-dependent form of regulated cell death that has become increasingly recognized as an important process mediating the pathogenesis and progression of numerous cardiovascular diseases, including coronary atherosclerosis, heart failure, arrhythmia and diabetic cardiomyopathy [33]. Increased...
(Fig.6a). ACC1 is at the rate-limiting step for the conversion of excess citrate into free fatty acids (Fig.6b); thus, any changes in its function or regulation could directly lead to excess lipid production and potentially explain the steatosis noted in the DM1-afflicted livers. ACC1 ...
Within these strata, congestive heart failure and furosemide use were the only variables independently associated with a significantly increased complication rate. Conclusions: Previous reports have overestimated the risk of arteriography for trauma or aneurysm but substantially underestimate the risk for ...
et al. Parathyroidectomy and heart rate variability in patients with stage 5 CKD. Clin J Am Soc Nephrol 8, 1378–1387, doi: 10.2215/cjn.10381012 (2013). 17. Dalamaga, M. et al. Leptin at the intersection of neuroendocrinology and metabolism: current evidence and therapeutic perspectives. ...
We found that cardiac function was impaired in adult cav1-KO fish, which showed a significantly decreased ejection fraction and heart rate. Using atomic force microscopy, we detected an increase in the stiffness of epicardial cells and cells of the cortical zone lacking Cav1/caveolae. This loss...