Immunoglobulin free light chains are increased in hypersensitivity pneumonitis and idiopathic pulmonary fibrosis. PLoS One 2011;6(9):e25392.Groot Kormelink T, Pardo A, Knipping K, Buendia-Roldan I, Garcia-de-Alba C, Blokhuis BR, et al. Immunoglobulin free light chains are increased in ...
Normalization of serum-free light chains in patients with systemic lupus erythematosus upon rituximab treatment and correlation with biological disease act... Increased free light chain (FLC) levels have been reported as useful in various autoimmune conditions. We investigated how FLC concentrations change...
The presence of intrathecal oligoclonal IgG and free light chains (FLCs) is a feature of MS and rituximab has been shown to be effective in MS. Plasma and B cells produce excess FLC that are excreted in the urine. Urinary FLC excretion is therefore a putative marker of MS activity. ...
Plasma cells, normal as well as clonal, secrete small amounts of kappa or lambda free light chains and these are quickly eliminated by the kidneys resulting in relatively low levels of circulating serum free light chains. However, in the presence of clonal plasma cells as with MGUS or MM, t...
The presence of intrathecal oligoclonal IgG and free light chains (FLCs) is a feature of MS and rituximab has been shown to be effective in MS. Plasma and B cells produce excess FLC that are excreted in the urine. Urinary FLC excretion is therefore a putative marker of MS activity. ...
(B) Positional movement of the Arg38 and Asn52 side chains identified in the G41S variant (yellow, PDB code: 3NWV)20 compared to the WT protein (light blue, PDB code: 3ZCF)21. H-bond networks are illustrated as blue (WT) and red broken lines (G41S), with H2O molecules shown ...
Effects of modulators of myosin light-chain kinase activity in single smooth muscle cells Phosphorylation of myosin light chains by a calmodulin-myosin light-chain kinase (MLCK) pathway is considered to be responsible for coupling increased calcium concentration with contraction in smooth muscle. This ...
A logical link between increased SOD2 in the diaphragm fibers and a reduction in MV-induced calpain activation is that oxidative stress promotes increased levels of cytosolic free calcium and therefore, increased calpain activation [13]. It follows that an increase in diaphragmatic levels of SOD2 ...
flexibilitiesandincreasedtrade connectionviatheglobal supply chains. daccess-ods.un.org daccess-ods.un.org 越来越多的国家诉诸非关税措 施,这可能是因为关税灵活性有限以及通过全球供应链建立的贸易关系增多。 daccess-ods.un.org daccess-ods.un.org ...
1d). Similar to other thermoplastic elastomers, physical crosslinking restricts the relative motion of polymer chains but maintains enough freedom for segments to enable elasticity in the material. Note that adding a tiny amount of chemical crosslinkers can further adjust the mechanical performance. As...