Aim of the present study was to investigate the influence of tobacco smoking during pregnancy on the O2-affinity and the CO2-binding of maternal blood. Using the derived results, a model describing the blood O2 dissociation curve for the conditions of increased concentrations of CO-hemoglobin and...
UA aggravates ISO induced heart failure and caused energy metabolism in zebrafish To further understand the specific mechanism how UA regulated FFA levels and heart fuction, zebrafish experiments were performed, as zebrafish embryo can tolerate the absence of blood flow for few days because its oxygen...
Inhibition of HO activity or chelation of cellular iron prior to hyperoxic exposure decreased reactive iron levels in the samples and significantly reduced oxygen toxicity. We conclude that there is a beneficial threshold of HO-1 overexpression related to the accumulation of reactive iron released in ...
Hydroxyapatite (HA) granules are frequently used in orthopedics and maxillofacial surgeries to fill bone defects and stimulate the regeneration process. Optimal HA granules should have high biocompatibility, high microporosity and/or mesoporosity, and high specific surface area (SSA), which are essential...
The product encoded by the X-linked inhibitor of apoptosis (XIAP) gene is a multi-functional protein which not only controls caspase-dependent cell death, but also participates in inflammatory signalling, copper homeostasis, response to hypoxia and control of cell migration. Deregulation of XIAP, ei...
For example, the sum of the ten cytokine levels was 1.8-fold higher for the Sod1−/− mice compared to the WT mice. Table 1. Cytokine levels in the blood of WT Young, WT Old and Sod1−/− mice. Empty CellG-CSFEotaxinGM-CSFIL-1αIL-1βIL-6KC (IL-8)MCP-1MIP-1TNFα...
Advances in unbiased large scale molecular approaches are proven to be successful in pinpointing individual or multiple genes associated with a disease [1]. Omics based assessment of human pathological conditions is usually based on tissue samples containing a mixture of cell types. Blood samples are...
Existing research has reliably demonstrated the respiratory and cardiovascular effects of carbon dioxide (CO2) inhalation at moderately increased levels, with documented physiological changes to heart rate, blood pressure, tissue pH, and blood solubility (for a review of the human health risks of acute...
We validate these results in human cancer cell lines. Moreover, resistance of cancer patients to olaparib is associated with high levels of RAF/MEK/ERK signaling, specifically in highly-aneuploid tumors. Overall, our study provides a comprehensive resource for genetically-matched karyotypically-stable...
Fig. 2: High-glucose diet in mice improves conventional chemotherapy response. a, b, Peripheral glucose levels (a) and body weights (b) of nude mice receiving normal or D30 water. Each dot represents the mean of weekly measurements of blood glucose per group (n = 5 mice per group)...