Habgood M.D. (1995) The nature of increased blood cerebrospinal fluid barrier exchange during CO2 inhalation in newborn and adult rats. Exp. Physiol. 80: 117-128.Habgood MD. The nature of increased blood-cerebrospinal fluid barrier exchange during CO2 inhalation in newborn and adult rats. ...
We describe a case of experimentally induced pre-syncope in a healthy young man when exposed to increased inspired CO2 in a background of hypoxia. Acute severe hypoxia (FIO2=0.10) was tolerated, but adding CO2 to the inspirate caused pre-syncope symptoms accompanied by hypotension and large redu...
"O2 response" may be one of the regulating mechanisms of cerebral blood flow like autoregulation and CO2 response. ICP decrease caused by hyperoxia in intracranial hypertension may depend upon the capacity of the "O2 response" of patients. Two main causes of the rebound phenomenon after ...
UA aggravates ISO induced heart failure and caused energy metabolism in zebrafish To further understand the specific mechanism how UA regulated FFA levels and heart fuction, zebrafish experiments were performed, as zebrafish embryo can tolerate the absence of blood flow for few days because its oxygen...
Blood 118, 5189–5200 (2011). Article CAS PubMed PubMed Central Google Scholar Stossel, C. et al. Spectrum of response to platinum and PARP inhibitors in germline BRCA-associated pancreatic cancer in the clinical and preclinical setting. Cancer Discov. 13, 1826–1843 (2023). Article CAS ...
Fetal arginine oxidation rate was calculated as net fetal 4CO2 excretion rate (equal to the product of umbilical blood flow and the concentration differ- ence of 14CO2 between umbilical arterial and venous blood) divided by the fetal plasma 14C-arginine specific activity. Uterine arginine clearance...
1.颅腔内容物体积增大:Brain体积增大(脑水肿),CSF增加(脑积水—脑脊液循环或吸收障碍所致的梗阻性脑积水和交通性脑积水),Blood增多(过度灌注和静脉回流受阻,如CO2蓄积,静脉窦血栓和脑肿胀) 2.颅内占位性病变:颅内血肿,脑肿瘤,脑脓肿 3.颅腔体积相对缩小:狭颅症,广泛凹陷性骨折 四.Pathophysiology of increased ICP...
Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs. We have generated mice homozygous for a disruption of the mdr1a (also called mdr3) gene, encoding a drug-transporting P-glycoprotein. The mice were viable...
The product encoded by the X-linked inhibitor of apoptosis (XIAP) gene is a multi-functional protein which not only controls caspase-dependent cell death, but also participates in inflammatory signalling, copper homeostasis, response to hypoxia and contr
Human blood plasma derived from peripheral blood (informed consent was obtained from the volunteer; the study adhered to the tenets of the Declaration of Helsinki, the Bioethics Committee approval no. KE-0254/187/10/2022) and PBS with calcium and magnesium (PBS+) were used in the evaluation ...