From 11 trials, comprising 21,299 individuals, four studies were included in the meta゛nalysis and reported 476 cases of cancer in 10,342 subjects in the lorcaserin group and 438 among 9429 individuals randomized to placebo (relative risk [RR]: 1.08; 95% confidence interval [95% CI]: 0.96...
BRCA1 Mutations and Breast Cancer in the General Population: Analyses in Women Before Age 35 Years and in Women Before Age 45 Years With First-Degree Famil... Studies of high-risk families with multiple early-onset cases of breast cancer have been useful for assessing the type and spectrum ...
Prevalence of BRCA1 and BRCA2 gene mutations in patients with early-onset breast cancer. BACKGROUND: Mutations in the BRCA1 and BRCA2 genes are found in most families with cases of both breast and ovarian cancer or with many cases of early-onset breast cancer. However, in an outbred ...
The researchers from Italy, Switzerland and France looked at 12,000 cases of cancer occurring in 13 different cancer sites (mouth andpharynx, nasopharynx, oesophagus, stomach, colorectum, liver, pancreas, larynx, breast, womb, ovaries, prostate and kidneys) between 1991 and 2009. They matched t...
followed 46,237 men from June 1986 to June 2008 in the Health Professionals Follow-up Study, and 107,339 women from June 1984 to June 2008 in the Nurses' Health Study. The researchers identified 36,102 new cases of non-melanoma skin cancer and 29,447 new cases of other primary cancers....
than 5,000 new cases of cancer in Spain each year and has a major impact on women’s health. Moreover, the incidence of this type of cancer is increasing, partly due to population ageing. As it is a hormone-dependent cancer, estrogens can play a role in its development...
Methodology/Principal findings We performed a meta-analysis of 6 case-control studies that included 4238 breast-cancer cases and 4469 case-free controls. We assessed the strength of the association, using odds ratios (ORs) with 95% confidence intervals (CIs). Overall, this meta-analysis showed ...
As seen with non-Hodgkin's lymphoma, a cancer known to be associated with HIV-1. Hodgkin's disease incidence was significantly higher in more recent years compared with earlier years. No cases of Hodgkin's disease were found among HIV-1 antibody-negative men, and Hodgkin's disease was ...
"The new Lyme disease case definition allows us to get a more accurate count of Lyme disease cases in high-incidence areas, which will improve our understanding of Lyme disease and its impact on people living in the United States," says Dr. Bobbi Pritt, director of the Clinical Parasitology...
We are exploring the hypothesis that p53 mutations in the nontumorous colonic tissue in noncancerous UC cases indicate genetic damage from exposure to exogenous and endogenous carcinogens and may identify individuals at increased cancer risk. We are reporting, for the first time, the frequency of ...