Genomic partitioning of inbreeding depression in humansLoic YengoJian YangMatthew C. KellerMichael E. GoddardNaomi R. WrayPeter M. Visscher
Thereby, we provide evidence for the existence of inbreeding depression in human fertility, also in relatively outbred and egalitarian communities... E Postma,L Martini,P Martini - 《Journal of Evolutionary Biology》 被引量: 45发表: 2010年 Inbreeding effects on prereproductive mortality: a case-co...
Much clinical and ethnographic evidence suggests that humans, like many other organisms, are selected to avoid close inbreeding because of the fitness costs of inbreeding depression. The proximate mechanism of human inbreeding avoidance seems to be precultural, and to involve the interaction of genetic...
(Caenorhabditis elegans: Dolgin et al., 2007; bark beetles: Peer and Taborsky, 2005; ornate dragon lizard: LeBas, 2002; song sparrow: Marr et al., 2002), sometimes in conjunction with inbreeding depression (humans: Helgason et al., 2008; Arabian oryx: Marshall and Spalton, 2000; fish: ...
Inbreeding depression-the reduced survival and fertility of offspring of related individuals-occurs in wild animal and plant populations as well as in humans, indicating that genetic variation in fitness traits exists in natural populati... D Charlesworth,JH Willis 被引量: 503发表: 2009年 Mate Choi...
However, large samples (e.g., 12,000–65,000) will be required to detect inbreeding depression for likely effect sizes, and so studies using Froh to date have probably been underpowered. 展开 关键词: Humans Pedigree Population Density Inbreeding Homozygote Multifactorial Inheritance Mutation Genetics...
one) individuals present in a population or at times when pollinators are rare, e.g., in ephemeral habitats. The disadvantage of inbreeding is that it reduces variation in a population and can even result in the accumulation of deleterious alleles, a phenomenon known as inbreeding depression. ...
Inbreeding depression can be readily measured in natural popula- tions, but little effort has been made to test for it in fungi, perhaps because a free-living haploid phase should eliminate many recessive deleterious alleles, the leading hypothesized basis of inbreeding depression (Charlesworth and ...
dominant effects, are more likely to show a large inbreeding depression effect because the cumulative expression of these recessive alleles can strikingly reduce the mean phenotypic value of the population [17]. This occurs because the heterozygote advantage on phenotypic expression masks the harmful eff...
In addition to inbreeding due to unions between close relatives, ancestral inbreeding from multiple remote ancestors makes a substantial contribution to the inbreeding coefficient of most kings. A statistically significant inbreeding depression for survival to 10 years is detected in the progenies of the...