CHANNELS 4 AND 5 GO TO GREAT LENGTHS IN COVERAGEBILL GRIFFITH
extracellular K+uptake, cell volume regulation, and facilitation of glutamate uptake, as well as in neurodegenerative diseases1,2,3,4,5,6. Although a pioneer developmental
In CAs, lower channel open probability results in reduced vasodilations to the TRPV4 channel agonist GSK1016790A (GSK101) compared to the MAs (Sonkusare et. al., 2014) suggesting that the activity of endothelial TRPV4 channels can be modulated by their environment. Further, TRPV4 channels ...
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In light of this, a new protein family, the chloride intracellular channels (CLICs), could be a promising class of therapeutic targets for its intrinsic individualities: CLIC1 and CLIC4, in particular, not only are overexpressed in specific tumor types or their corresponding stroma but also ...
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Using the 2.9 Å resolution structure of the membrane-intrinsic protein-cofactor complex photosystem II (PSII) from the cyanobacterium Thermosynechococcus elongatus, we calculated and characterized nine possible substrate/product channels leading to/away from the Mn4Ca cluster, where water is oxidized to...
In this paper, we consider the human isoform 3A4. It lies in the human liver and is estimated to contribute to the phase I metabolism of roughly half of the drugs on the market [22,23]. The other isoforms accounting for more than 90% of the oxidation of drugs are 1A2, 2A6, 2C9...
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Video S1. Propagation of the cAMP signal in the C-terminal cytosolic region of HCN4 and HCN1, related to Figure 3 Video S2. Pore opening in HCN4 channels, related to Figure 4 Video S3. MD simulation in K + solution, related to Figure 6 Video S4. MD simulation in Na + solution, ...