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Regulation of G protein-initiated signal transduction in yeast: paradigms and principles. All cells have the capacity to evoke appropriate and measured responses to signal molecules (such as peptide hormones), environmental changes, and other ex... HG Dohlman,JW Thorner - 《Annual Review of Bioch...
Global roles of Ste11p, cell type, and pheromone in the control of gene expression during early sexual differentiation in fission yeast Fission yeast cells belong to one of two specialized cell types, M or P. Specific environmental conditions trigger sexual differentiation, which leads to a... ...
To further understand the molecular regulatory mechanism of OsUBC12 protein, we attempted to identify its ubiquitination targets, using OsUBC12 as bait to screen a yeast two-hybrid (Y2H) library generated from rice seed cDNA, and isolated 67 candidate clones. Expressed sequence tags (ESTs) from ...
Genetic control of the cell division cycle in yeast: IV. Genes controlling bud emergence and cytokinesis Temperature-sensitive mutations in one gene (cdc1) of Saccharomyces cerevisiae confer a defect in bud emergence. Asynchronous cultures of cells defective in cdc1 collect uniformly as unbudded ...
Improvement of chilling tolerance is a key strategy to face potential menace from abnormal temperature in rice production, which depends on the signaling network triggered by receptors. However, little is known about the QTL genes encoding membrane compl
The yeast P4-ATPases in particular have been indispensable for understanding how phospholipid headgroups and backbones are coordinated/selected during transport. In this study, we have identified a conserved clade of yeast and human P4-ATPases that transport GlcCer. Further, a central glutamine ...
While paralog GIs are still poorly characterized in mammalian cells, the extensive degree of duplication in the human genome is similar to that seen in yeast (Dennis and Eichler, 2016; Lan and Pritchard, 2016; Singh et al., 2012), so experimental evaluation of human cells is likely to also...
Briefly, In antigen-presenting cells (APCs), (1) LNPs containing circRNA vaccines form endosomes in the cytoplasm. Then, (2) endosomes release the circRNA vaccine (endosome escape). Subsequently, (3) encoding sequences in circRNA were translated into antigenic proteins/peptides by ribosomes. (4...
(encoding a vital enzyme in the NAD+salvage pathway) are essential for CR-mediated lifespan extension in both yeast and worms.36,60,61NAD+levels decrease with age and age-associated diseases.35Specifically, senescent cells progressively accumulate in liver and visceral white adipose tissue (WAT) ...