G1 cell cycle arrest is, in most cases, a result of the induction of the CDKN1A gene, which encodes the cyclin-dependent kinase inhibitor WAF1 (also known as p21; Richon et al. 2000). Treatment of cells with HDACi can also lead to the induction of apoptosis. The inhibitors can ...
In this study we highlighted how the inhibition of multiple CDKs might be more beneficial for the treatment of MB than specific CDK4/6 inhibition, which is currently the only cell cycle targeted therapy pursued in clinical trials with palbociclib (NCT03709680). Starting from an unbiased in silic...
Recently, the use of high-dose post-transplant cyclophosphamide following infusion of a T-cell replete graft is revolutionizing haplo HSCT.21,22 However, there remain several unmet needs to improve haplo HSCT outcome such as improving post-transplant immune reconstitution, which may also decrease ...
In this review, we provide an overview of the different BsAb formats and the various BsAbs, targeting different MM-associated antigens, which are currently evaluated in clinical studies. We will also discuss the challenges of BsAbs, for instance, emerging resistance mechanisms. Finally, the future...