The 9-1-1 DNA checkpoint clamp is loaded onto 5′-recessed DNA to activate the DNA damage checkpoint that arrests the cell cycle. The 9-1-1 clamp is a heterotrimeric ring that is loaded in Saccharomyces cerevisiae by Rad24-RFC (hRAD17-RFC), an alternate
A central question in neuroscience is how synaptic plasticity shapes the feature selectivity of neurons in behaving animals1. Hippocampal CA1 pyramidal neurons display one of the most striking forms of feature selectivity by forming spatially and contextually selective receptive fields called place fields...
Nguyen Viet Dung: Over the past 75 years since the founding of the People's Republic of China, Vietnam has witnessed Chinese people compose a magnificent chapter in China's revolution, construction and reform, attaining miraculous accomplishments. It is not easy to make an assessment of the dev...
Vietnam has witnessed Chinese people compose a magnificent chapter in China's revolution, construction and reform, attaining miraculous accomplishments. It is not easy to make an assessment of the development of the Chinese economy over the past 75 years in just a few words, however ...
before expanding the range of projects to include new structures. While his built body of works demonstrates many of the core principles of good architecture, the ongoing projects reveal an equally relevant narrative: that of his direction moving forward and the way in which his approach to these...
pressure loads update direction based on the displacement. (Forces are applied to a node which does not have an orientation. The direction of force loads does not update.) Large Displacements = Off nonlinear material properties included in the analysis. the stiff...
which these later determinations emerge, the life of my eyes, hands, and ears, which are so many natural selves.”[14] Returning to the beginning of this paper, Merleau-Ponty said that only the painter is obligated to see things without giving value. When we say that an image is ...
The direction of the watershed and geomorphological zoning, as well as the flow direction of karst water and the water system, are influenced by the activities and tectonic patterns of larger-scale faults. The geometric morphology of the river network system is not strictly limited to larger-...
DNA replication (Supplementary Fig.1a). In all conditions, changes in total DNA correlated with changes in EdU-labeled DNA, indicating newly synthesized DNA was quantitatively labeled (Supplementary Fig.1b). Importantly, cells remained in a G1-like state after bypass of CDK and DDK regulation ...
To quantify the changes in podosome protrusiveness upon loss of integrin tension, we synthesized PC probes lacking the quencher (Fig. 5d). Here, Cy3B intensity is insensitive to tension, and changes in signal exclusively report DNA density. Hence, probe depletion radius provided a proxy for the...