The term "objective in vivo" is given to a category of tests which is employed to quantify consumers' evaluation of specific product attributes under controlled, simulated use conditions. This helps to bridge the gap between tests which are designed to measure the physical or functional aspects ...
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Vivisection experiments fall into three general categories: attempts to test the toxicity of drugs and substances (Animal Testing); attempts to study human disease (Experimental Research on Animals); and attempts to teach medical students human anatomy and surgical techniques (Dissection and Practice Sur...
to test if this new channel architecture could trigger separation pattern of ingrowth also in vivo. Our results showed that this new method enabled the re-growth of neurites into channels with gradually diminished width (80, 40 and 20 µm) and facilitated the separation of the axonal bundles...
An approach that allows the simultaneous testing of more formulations and the preliminary evaluation of the efficacy before or in combination with in vivo studies (pre-clinical test methods). In vivo efficacy instrumental evaluations (image analyzer and bio-engineering technologies). Visual evidence ...
In vivotesting at three different time points (2, 8, and 12 weeks) revealed the highest corrosion rate, the most surface product, and a distinct wavy surface pattern for as-cast Mg pins (Fig.S2). There were no significant signs of inflammation, hemorrhage, necrosis, or discoloration in the...
In vitro dissolution testing conditions that reflect and predict in vivo drug product performance are advantageous, especially for the development of paediatric medicines, as clinical testing in this population is hindered by ethical and technical considerations. The aim of this study was to develop an...
Invitro-invivocorrelationIntroductionForapprovalo genericdrugproducts,bioequivalencetestingisconsideredasasurrogate orclinicalevaluationo thetherapeuticequivalenceo drugproductsbasedontheFundamentalBioequivalenceAssumptionthatwhentwodrugproducts(e.g.,abrand-namedruganditsgenericcopy)areequivalentinbioavailability,theywill...
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These three tests are applied to materials or medical devices, if there is a need for classification of plastics and other polymers based on in vivo biological reactivity testing.For the purpose of this chapter, these definitions apply: the Sample is the specimen under test or an extract ...