European Journal of PharmacologyFlorijn WJ, De Boer T, Tonnaer JADM, Van Nispen JW, Versteeg DHG (1990) The in vitro binding of dopaminergic ligands to dopamine D-2 receptors is inhibited by ACTH/MSH-like peptides. Eur J Pharmacol 183:1407–1408...
3.1. Preparation of NCDs The preparation of NCDs involves the selection of the appropriate methods of synthesis that is either Bottom-up or Top-down approach as per the required application, followed by the removal of large-sized particles. In the Bottom-up approach, the hydrothermal method is ...
#IESYMPOSIUM @pharma_BI @AVIVA1950 Michael Dustin @Oxford Delivery of T cell Effector function through extracellular vesicles Synaptic ectosome biogenisis Model: T cells: DOpamine cascade in germinal cell delivered to synaptic cleft – Effector CD40 – Transfer is cooperative Aviva Lev-Ari @AVIVA...
animals, and microbes. Though melatonin was discovered in plants decades after its discovery in mammals, its presence has now been confirmed in almost all plant families. Despite this, thein vitroandin vivomechanisms of action of melatonin are still poorly defined. Although...
of pre-miRNA is cleaved to the short miRNA duplex that is approximately 22 nt in length. In the next step, the miRNA is incorporated into the RNA-induced silencing complex (RISC), and following unwinding and strand selection, the mature miRNA can recognize the target sequence that is ...
G protein-coupled receptors (GPCRs), the largest family of human membrane proteins and an important class of drug targets, play a role in maintaining numerous physiological processes. Agonist or antagonist, orthosteric effects or allosteric effects, and
Traditional Chinese Medicines (TCMs) have been used for centuries for the treatment and management of various diseases. However, their effective delivery to targeted sites may be a major challenge due to their poor water solubility, low bioavailability,
Chemokines are an indispensable component of our immune system through the regulation of directional migration and activation of leukocytes. CXCL8 is the most potent human neutrophil-attracting chemokine and plays crucial roles in the response to infecti
Receptor transfer between cells by means of EVs is a mechanism of intercellular signaling [26,29]. EVs may also impact recipient cells by reducing the inflammatory response. Renal proximal tubular cells release exosomes, in the presence of a dopamine receptor agonist, that when incubated with ...
Applications of novel techniques like optogenetics, chemogenetics, and gene-editing tools in epilepsy treatment are also introduced. We will also address the challenges of integrating basic research and clinical implementation in each part based on experimental results. 2. Selection and design of ...