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必应词典为您提供in-vitro-kinase-assay的释义,网络释义: 体外激活性测试;细胞外激酶试验;离体磷酸酶活性分析;
AMP-activated protein kinase: a cellular energy sensor that comes in 12 flavours. FEBS J. 2016;283:2987–3001. Article CAS PubMed PubMed Central Google Scholar Tian S, Zhou X, Phuntsok T, Zhao N, Zhang D, Ning C et al. Genomic Analyses Reveal Genetic Adaptations to Tropical Climates ...
tabelisib, KU-0063794, AZD8055, and BYL-719 were observed, suggesting PI3K-AKT inhibitors could mitigate oxaliplatin resistance (FigureS10C-D). In vitro AKT inhibitor Ipatasertib was used to confirm the drug-resistant effect of the PI3K-AKT...
体外研究(In Vitro) Multi-kinase-IN-1 (Compound 11k) (0-5 µg/mL, 0-72 h) induces antiproliferation and cytotoxicity in a dose- and time-dependent manner in HT-29 cells, and is much less toxic to normal colorectal mucosa epithelial cells[1]. Multi-kinase-IN-1 (0-3 µg/mL, ...
Theaflavin-3, 3′-digallate suppresses human ovarian carcinoma OVCAR-3 cells by regulating the checkpoint kinase 2 and p27 kip1 pathways. Molecules 2019, 24, 673. [Google Scholar] [CrossRef] [PubMed] [Green Version] Lemieux, I. Energy partitioning in gluteal-femoral fat: Does the metabolic...
Kinase AssayBinding affinity assays Binding affinities (Kior IC50) of ABT-199 against different isoforms of Bcl-2 family are determined with competitive fluorescence polarization assays. The following peptide probe/protein pairs are used: f-bad (1 nM) and Bcl-xL (6 nM), f-Bax (1 nM) and ...
IHC immunohistochemistry, CaMKII calcium/calmodulin-dependent protein kinase II, PV parvalbumin, vCA1 ventral hippocampal CA1, GCaMP6f genetically encoded calcium indicators, hTau human tau Full size image Next, we analysed the real-time activity of excitatory and PV neurons in the vCA1 during ...
Inhibition of PI3-kinase prevented cell differentiation and fusion in control cells, which was attenuated in PKCθshRNA cells. Thus, with reduced PKCθ, differentiation and fusion occur in the absence of PI3-kinase activity. Inhibition of the ERK kinase, MEK1/2, impaired differentiation and cell...
[33], the antiapoptotic activity of NFκB involves suppressing the accumulation of ROS and controlling the activation of the c-Jun N-terminal kinase (JNK) cascade, and in this way, suppressing the activity of TNFα. The same mechanism may explain our results. The combination of trans-...