In vitro-in vivo correlation and dissolution studies with oral theophylline dosage forms. J Pharm Sci. 1984: 74; 161-164.El-Yazigi A, Sawchuk RJ. In vitro-in vivo correlation and dissolution studies with oral theophylline dosage forms. J Pharm Sci 1985;74(2):161-4....
Comparative in vitro dissolution study of some ciprofloxacin generic tablets under biowaiver conditions by RP-HPLC. 2011; 2(12): 3129-3135.Tanjinatus SO, Ahsanul HI, Irin D, et al. Comparative in vitro dissolution study of some ciprofloxacin generic tablets under biowaiver conditions by RP-...
we carried outin vitroandin vivoexperiments to test the biocompatibility of Nb-containing glass. In thein vitroapproach we treated human embryonic stem cells (hESCs), CCTL12, with the dissolution products of Nb-
In-vitro bioactivity, biocompatibility and dissolution studies of diopside prepared from biowaste by using sol–gel combustion method Author links open overlay panelRajan Choudhary a, Jana Vecstaudza b, G. Krishnamurithy c, Hanumantha Rao Balaji Raghavendran c, Malliga Raman Murali c, Tunku ...
The GRAS nutrient formulation used in the clinical study had in vitro dissolution characteristics suggesting that the majority of the nutrient load would be released in vivo in the small intestine within 3 h of ingestion. However, non-sucrose nutrient release from the particles may not have ...
This manuscript details the development of a Multiple Level C IVIVC for the amorphous solid dispersion formulation of suvorexant, a BCS class II compound, and its application to establishing dissolution specifications and in-process controls. Four different 40mg batches were manufactured at different ...
pharmaceutical solids' in vitro dissolution ‐ active pharmaceutical ingredient (API), rate‐limiting stepin vitro–in vivo correlation (IVIVC) ‐ rational relationship, biological outcome or fateautomated sampling ‐ automation, good quality control of dissolution data...
1. Identify a model PROTAC that can potentially demonstrate activity based on knowledge in PROTAC design or in vitro binding studies. 2. Perform a time course study with 2–3 doses of the model PROTAC based on affinities of the ligands selected. 3. Monitor ubiquitination and degradation ...
linearin vitro/in vivocorrelation (IVIVC) (R2value of 0.98) compared with a “hockey stick” profile of the USP test. This study therefore concluded that the newly developed Aston test is an accurate, repeatable, relevant and robust test method for assessing ODT disintegration time which will ...
The lack of therapeutic alternatives for the treatment of Chagas disease, a neglected disease, drives the discovery of new drugs with trypanocidal activity. Consequently, we conducted in vitro studies using UBMC-4, a potentialTrypanosoma cruziAKT-like pleckstrin homology (PH) domain inhibitory compound...