This equation is based on the diffusion layer concept and Fick's second law, which laid the foundation for dissolution modeling.In studying dissolution of spherical particles, Hix- son and Crowell (6) derived the cubic-root law of dissolution, by applying the relationship between the surface ...
The dissolution of uranium by the batch method appears highly dependent on experimental procedure, invalidating interpretation of in vitro batch procedures in terms of dissolution half-time. It is suggested that the temperature of form ation may determine the degree of dissolution of the second ...
This guidance is developed for immediate release (IR) dosage forms and is intended to provide (1) general recommendations for dissolution testing; (2) appr... CFD Evaluation 被引量: 737发表: 1997年 FIP/AAPS Guidelines to dissolution/in vitro release testing of novel/special dosage forms FIP/...
In the present invention, an attempt made to evaluate the correlation between in vitro dissolution and in vivo dissolution, by incorporating enzymes to match the human body physiological conditions. Dipyridamole Extended release Capsules evaluated for dissolution in simulated fasting change over condition ...
Comparison of the in vitro dissolution behaviour of various indomethacin formulations with their in vivo bioavailability 来自 Wiley 喜欢 0 阅读量: 25 作者: J.,S.,ROWE,J.,E.,CARLESS 摘要: The effects of the core to colloid wall ratio and particle size of the core on the in vitro release ...
The aim of this study was the comparison of in vitro dissolution and in vivo bioavailability of two different brands of diclofenac sodium (CAS 15307-86-5) enteric coated tablets in healthy male Iranian volunteers in a single-dose, randomized, open-label, single blind study, which was conducted...
This manuscript details the development of a Multiple Level C IVIVC for the amorphous solid dispersion formulation of suvorexant, a BCS class II compound, and its application to establishing dissolution specifications and in-process controls. Four different 40mg batches were manufactured at different ...
网络体外释放;体外溶出度;体外溶出 网络释义 1. 体外释放 体外释放机制,mechanis... ... ) drug release in vitro 体外释放 )in vitro dissolution体外释放) release in vitro 体外释放 ... www.dictall.com|基于 1 个网页 2. 体外溶出度 体外溶出,in vitro... ... ) dissolution in vitro 体外溶出度...
Methods of comparing in vitro dissolution profile data are of interest in the development of Extended Release dosage formulations. One is usually interested in determining if the dissolution profile f T O'Hara,A Dunne,A Kinahan,... - 《Oxygen Transport to Tissue XXXIII》 被引量: 30发表: 1997...
2.9. Application to in-vitro dissolution studies The dissolution testing of FAV from Avigan® tablets was conducted at 37 ± 0.5 °C with stirring speed of 50, 75 or 100 rpm using USP apparatus I and II. Dissolution media including deionized water, 0.1 N HCl pH 1.2, acetate buffer pH ...