Pharmaceutical sciences Development of an in vitro dissolution model to predict the in vivo behavior of poorly soluble compounds UNIVERSITY OF THE PACIFIC Bhaskara Jasti VanganiSarojOne of the challenges of biopharmaceutics research is correlating in vitro drug release information with the in vivo drug...
In vitro dissolution models for the prediction of in vivo performance of an oral mesoporous silica formulation [J].McCarthy C A, Faisal W, O'shea J P, et al.Journal of Controlled Release, 2017, 250: 86-95.IF=7.901 26. 体外-体内相关性IVIVC:一般概念,方法,在法规监管中的应用 In vitro–...
Typical two-dimensional (2D) culture models of skeletal muscle-derived cells cannot fully recapitulate the organization and function of living muscle tissues, restricting their usefulness in in-depth physiological studies. The development of functional 3
The application of in vitro models in drug permeability studies represents a useful screening tool for assessing the biopharmaceutical appropriateness of new chemical entities (NCEs). Of note, there remains an ever-increasing number of NCEs which exhibit poor aqueous solubility. However, in their class...
Comparison of in vitro dissolution profiles by ANOVA-based, model-dependent and -independent methods In this study, the aim was to apply different comparison methods to dissolution profiles of immediate release commercial film-coated tablets of naproxen so... N Yuksel,AE Kanik,T Baykara - 《Inte...
Dissolution assay development for in vitro-in vivo correlations: theory and case studies. In: Advances in experimental medicine and biology; in vitro-in vivo correlations, vol. 423. New York: Plenum Press; 1997. p. 17–30.Rohrs BR, Skoug JW and Halstead GW. Dissolution assay development ...
网络释义 1. 体外释放 体外释放机制,mechanis... ... ) drug release in vitro 体外释放 )in vitro dissolution体外释放) release in vitro 体外释放 ... www.dictall.com|基于 1 个网页 2. 体外溶出度 体外溶出,in vitro... ... ) dissolution in vitro 体外溶出度 )in vitro dissolution体外溶出度....
In this review, we discuss how recent in vitro models have addressed critical questions regarding the role of the non-collagenous proteins in controlling mineralization, the nature of the interactions between amorphous calcium phosphate and collagen during the early stages of mineralization, and the ...
This manuscript details the development of a Multiple Level C IVIVC for the amorphous solid dispersion formulation of suvorexant, a BCS class II compound, and its application to establishing dissolution specifications and in-process controls. Four different 40mg batches were manufactured at different ...
Effective exposure of chemicals in in vitro cell systems: A review of chemical distribution models SusanaProençaBeate I.EscherFabian C.FischerCiaránFisherSébastienGrégoireNicky J.HewittBeateNicolAliciaPainiNynke I.Kramer, inToxicology in Vitro, 2021 ...