Drug release is determined by formulation factors such as disintegration/dissolution of formulation excipients or drug diffusion through the formulation. In vitro dissolution testing should thus provide predictions of both the drug release and the dissolution processes in vivo.Ch. Taraka Ramaro...
problem.PossibleproblemsincludephysicaldegradationofINVITROEVALUATION thecompactbycracking,delaminating,ordisintegration. Downward(negativesecondderivative)curvatureofthedis- solutionprofileisoftenindicativeofatransformationofthe solidformofthecompactatthesurfaceorwhensaturationDissolutionandDrugReleaseTesting— ofthedissolutio...
In Vitro Drug Release Testing of Special Dosage Forms A method to establish the in vitro-in vivo relationship of oral extended-release products is proposed.The approach utilizes incremental amounts of drug rel... G Martin - 《Dissolution Technologies》 被引量: 0发表: 2021年 Book Review: "In...
The current review provides a good insight idea anatomy and nature of oral cavity, the design of appropriate in vitro and in vivo methods to evaluate the behaviour of these bioadhesive delivery systems. The development of a range of in vitro methods is outlined including disintegration/dissolution ...
The in-vitro dissolution tests indicate that all five matrix formulations prolong the release of diclofenac sodium. The main factors controlling drug release were the HPMC viscosity grade and the amount of HPMC used. The larger the amount of high viscosity grade HPMC used, the slower the ...
dissolution of the Mg core, leading to a prolonged micromotor lifetime of ~6 min. The in vivo self-propulsion in the gastric fluid of a stomach and the corresponding drug delivery process from the PLGA layer of the Mg-based micromotors are illustrated schematically in Fig.1band Supplementary...
A diagram illustrating a typical set up for the standard USP disintegration test for solid oral dosage forms that is also recommended for ODT disintegration testing. It shows how the basket would typically by placed within the beaker/water bath, and how the dissolution vessels are arranged within...
Important Factors for Development of in vitro Release Testing Method for LAIs Drug stability The stability of both released and unreleased drugs is important during design of the release testing method for LAIs. The drug can be chemically degraded or physically denatur...
and osteostimulation, that are essential for osteointegration of medical materials for bone replacement. Thein vitroapproach consisted of treating human embryonic stem cells (hESCs) with the dissolution products from the glass and verifying cell viability and osteogenic differentiation. For thein vivoassay...
Various computational tools can resolve problems encountered in the formulation design area, such as stability issues, dissolution, porosity, and so on, with the help of QSPR [83]. Decision-support tools use rule-based systems to select the type, nature, and quantity of the excipients depending...