Such transformations and the bioaccessibility of acyl-quinic acids from Tudela artichoke have been demonstrated in vitro (Domínguez-Fernández, Ludwig, et al., 2021), but not in vivo. Previous studies investigating the acyl-quinic acid bioavailability have focussed on interventions with coffee (...
The reproductibility of the technique was less than 5% (n = 3).The results of this work propose a new technique to determine the local bioavailability of 5-MOP in intersitial fluids, which are the target of its pharmacological action....
Jedidi, H.; Kheadr, E.; Gagnon, F.; Van Calsteren, M.R.; Farnworth, E.; Fliss, I. In vitro study of the bioavailability of fatty acids in cow milk containing conjugated linoleic acids produced in vivo or added in synthetic form. Int. Dairy J. 2014, 36, 95-100. [CrossRef]...
We assessed the bioavailability of lutein from lutein-fortified fermented milk using in vivo and in vitro approaches. Twenty-four volunteers were randomized to take lutein-fortified fermented milk at two levels of fortification. Single-dose bioavailability study (2×100 ml, ca. 8 or 16 mg of lut...
FORMULATION AND IN-VITRO/IN-VIVO ASSESSMENT OF ENHANCED BIOAVAILABILITY OF LACIDIPINE USING NANO PURE TECHNIQUE 来自 Semantic Scholar 喜欢 0 阅读量: 30 作者:SC Dinda,SK Panda 摘要: The objective of this study was to formulate and evaluate a novel drug solubilization platform (so called Nano- ...
Evaluation of SBRC-gastric and SBRC-intestinal methods for the prediction of in vivo relative lead bioavailability in contaminated soils In this study, lead (Pb) bioaccessibility in contaminated soils was assessed using an in vitro method (SBRC) encompassing gastric (SBRC-G) and intestinal (.....
(GI) tract, and decreased bioavailability have limited its usage as a clinical treatment29. Previous studies had tried to overcome the obstacles of the clinical application of curcumin by improving its bioavailability, increasing the plasma concentration, enhancing the cellular permeability, and ...
in vitro13,14. However, the majority of these ERα PROTACs represent in vitro tools rather than compounds for future clinical development. The exception is ARV-471, which uses an IMiD binder to recruit cereblon E3 ligase and has shown oral bioavailability both preclinically and more recently in...
Sannino A, Madaghiele M, Lionetto M, Schettino T, Maffezzoli A (2006) A cellulose-based hydrogel as a potential bulking agent for hypocaloric diets: an in vitro biocompatibility study on rat intestine. J Appl Polym Sci 102:1524–1530 Article CAS Google Scholar Sannino A, Demitri C, ...
Oral bioavailability (OB) and drug-likeness (DL) are very important pharmacokinetic parameters and key indicators in ADME process [29]. According to existing studies, OB ≥ 30% and DL ≥ 0.18 were used as screening criteria for drug compounds in this study. Identification of targets ...