School of Biological Sciences, Seoul National University, Seoul, Republic of Korea Choongwon Jeong Choongwon Jeong
Castellano, J. M. et al. Human apoE isoforms differentially regulate brain amyloid-β peptide clearance. Sci. Transl Med. 3, 89ra57 (2011). CAS PubMed PubMed Central Google Scholar Hashimoto, T. et al. Apolipoprotein E, especially apolipoprotein E4, increases the oligomerization of amyloid...
Consequently, the innate immune system fails to prime an adaptive immune response in time to clear the virus from the infected CNS. Unlike rabies, HSV infection initiates a fulminant inflammatory cascade, recruiting innate immune cells and activating adaptive immune mechanisms to the infected CNS area...
RNA transcriptomic and real-time PCR data from explanted livers point to active AAV2 infection, although we did not detect AAV2 proteins by immunohistochemistry (Extended Data Fig. 6b) or proteomics (Extended Data Fig. 8) or any viral particles. The abundant AAV2 genomes in the explanted liver...
2014). The ability of R-loops to trigger the formation of heterochromatin, histone H3 S10 phosphorylation, and chromatin condensation (Castellano-Pozo et al. 2013) may facilitate transcript silencing through establishment of repressive chromatin, but may also lead to replication fork stalls and DNA ...
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Siepel A, Kent WJ, Haussler D, Eyras E, Castelo R, Abril JF, Castellano S, Camara F, Parra G, Guigo R, Bourque G, Tesler G, Pevzner PA, Smit A, Fulton LA, Mardis ER, Wilson RK: Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolu...
Artificial intelligence (AI) is becoming increasingly important, especially in the medical field. While AI has been used in medicine for some time, its growth in the last decade is remarkable. Specifically, machine learning (ML) and deep learning (DL) te
(2016). A novel approach to safety stock management in a coordinated supply chain with controllable lead time using present value. Applied Stochastic Models in Business and Industry, 32, 99-112.Braglia, M., D. Castellano, and M. Frosolini. 2016. A novel approach to safety stock management ...
Castellano BM, Thelen AM, Moldavski O, Feltes M, van der Welle RE, Mydock-McGrane L, et al. Lysosomal cholesterol activates mTORC1 via an SLC38A9-Niemann-Pick C1 signaling complex. Science. 2017;355:1306–11. Article CAS PubMed PubMed Central Google Scholar Ng MYW, Charsou C, Lapa...