coli was seen in the livers of BDL mice. Although the serum IL-12 and IL-18 levels after E. coli challenge in BDL mice were higher than those in sham mice, the IFN-gamma level was greatly suppressed. However, exogenous IFN-gamma injection significantly increased BDL mouse survival after E...
Biochemical changes in the liver of mice fed mirex - Byard, Koepke, et al. - 1975 () Citation Context ...xic in short-term, in vitro tests (9,10) and inhibits gap junctional communication (11), two characteristics of tumor promoters. Mirex induces proliferation of hepatocyte smooth ...
Dichloromethane (DCM) has been evaluated for its ability to initiate unscheduled DNA synthesis (UDS) in the livers of male mice and rats in vivo. Two types of experiment were conducted. In the first, Alpk:AP rats were exposed by oral gavage to 100, 500, or 1,000 mg/kg DCM and hepatoc...
Deposition of collagen-I could be observed in the livers of mice treated T0 and CCl4-treated group (wpi http-equiv="content-type"
(Fasn), leading to repressed fatty acid metabolism220. Consistently, it has been shown that METTL3 expression and overall mRNA m6A methylation level was upregulated in the livers of mice with high fat diet (HFD)-induced metabolic disorders, while hepatocyte-specific knockout of METTL3 alleviated...
Silica was reported to accumulate in the spleens of rats after they received SAS by gavage for 84 days[32]. In another study, mesoporous silica NPs were absorbed into the intestinal tract and persisted in the livers of mice[33]. The kidneys, liver, lungs, and spleen were found to be ...
Abstract Background Magnetic resonance imaging (MRI) contrast agents contain magnetic molecules such as iron (Fe) or gadolinium (Gd) that are injected in vivo into rats or mice to study their distribution inside the liver. Fluorescent europium (Eu) can be used as a model of Gd to obtain com...
We have previously characterized TH-regulated global gene expression in the livers of juvenile mice [18]. This study evaluated transcriptional effects in animals in which TH production had been severely depressed through a relatively long-term treatment with a high concentration of an antithyroid drug...
The investigators found that antibiotic treatment increased the numbers of a type of immune cell called NKT cells in the livers of the mice. In all three mouse models, the reduction in liver tumor growth that resulted from antibiotic treatment was dependent on these NKT cells. ...
The liver fibrosis mice were generated by intraperitoneal injection of CCl4 in olive oil (1:3) twice weekly at equal intervals for 6 weeks (1 μL/g). Mice in the control group were injected with the same volume of olive oil. After 6 weeks, mice were sacrificed and livers were collected...