Self-renewal is a crucial property of glioblastoma cells that is enabled by the choreographed functions of chromatin regulators and transcription factors. Identifying targetable epigenetic mechanisms of self-renewal could therefore represent an important step toward developing effective treatments for this univ...
Workflow diagram. TKIs: tyrosine kinase inhibitors; Platinum-based chemo: platinum-based chemotherapy; PD-L1: programmed cell death-ligand 1; IHC: Immunohistochemistry; NGS: Next-Generation Sequencing Full size image Clinical and pathological data, including sex, age at diagnosis, smoking history, tumo...
The defining features of Alzheimer’s disease (AD) include alterations in protein aggregation, immunity, lipid metabolism, synapses, and learning and memory. Of these, lipid abnormalities are the least understood. Here, we investigate the role of Stearoy
Collaborative Facial Landmark Localization for Transferring Annotations Across Datasets In this paper we make the first effort, to the best of our knowledge, to combine multiple face landmark datasets with different landmark definitions into a super dataset, with a union of all landmark types comput...
Data from each brain region was processed and gene sets were created separately (i.e., references to all cells in the following mean all cells in a particular brain region). We first excluded samples not assigned to annotated clusters. We then excluded genes whose sum of raw count across ...
A learnable filter function is first proposed in GFL [42] to develop the readout operation. Under their framework, the learning signal can backpropagate through the computation of persistent homology, making it possible to learn a proper filter function for improved performance. Following this line...
Following the analysis of identified articles, we overview the sound datasets, feature extraction methods, data augmentation techniques, and its applications in different areas in the sound classification research problem. Finally, we conclude with the summary of SLR, answers to research questions, and...
GROUNDING IN HIGH SPEED SYSTEMS Walt Kester, James Bryant The importance of maintaining a low impedance large area ground plane is critical to practically all analog circuits today, especially at high speeds. The ground plane not only acts as a low impedance return path for high frequency ...
Muscle invasive bladder cancer (MIBC) is a life-threatening malignant tumor characterized by high metastasis rates, poor prognosis, and limited treatment options. Immune checkpoint inhibitors (ICIs) targeting PD-1 and PD-L1 represent an emerging treatmen
The CellChat package (v1.6.1) [34] in R was utilized to infer ligand-receptor pair communication between different cell subtypes and create a cell communication network diagram. Through CellChat algorithm calculations, outgoing or incoming signal strength was compared to assess the overall signal ...