Obesity is a prominent risk factor for male infertility, and a high-fat diet is an important cause of obesity. Therefore, diet control can reduce body weight and regulate blood glucose and lipids, but it remains unclear whether it can improve male fertil
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with normal saline (0.1 mL); the BPH model group, the rats were treated with TP (s.c., 10 mg/kg alternate days); two positive control groups, the rats were treated with TP and received a treatment with finasteride (1 mg/kg per day) or Pule’an (i.g., 460 mg/kg per day) by...
The treatment regime is shown in Fig. 1A, and the rationale for the doses of DHT and INS has been previously described [29,30,31, 36, 41]. Chronic exposure of pregnant rats to DHT and INS results in hyperandrogenism and insulin resistance [29, 30], which is equivalent to that found...
We used C3H/HeN (Janvier, Roubaix, France) mice known to be excellent breeders to minimize stress induced by the treatment during perinatal period. Perinatal experiment was conducted as previously described25, excepted that pregnant and lactating mice were daily exposed by dermal route (instead of...
Stress and relapse to drug seeking in rats: studies on the generality of the effect Rationale: Intermittent footshock reinstates drug-taking behavior in rats, but not behaviors previously maintained by food reinforcers. Here we tested fur... U Shalev,D Highfield,J Yap,... - 《Psychopharmacolog...
Pulses of blue (445 nm) light trigger precisely timed depolarizations and action potential firing of the DVMN neurons transduced to express ChIEF (11). Male Sprague-Dawley rats (150 to 200 g; n = 68) were anesthetized with a combination of ketamine (60 mg/kg intramuscularly) and ...
One strategy to vary the amount of in vivo protein synthesis as well as its duration is by changing the route through which mRNA-LNP vaccines are delivered to the body [201]. In the experiment, the half-life of mRNA-encoded firefly luciferase was roughly threefold longer after intradermal inj...
Deep brain stimulation (DBS) relieves motor dysfunction in Parkinson’s disease, and other movement disorders. Here, we demonstrate the potential benefits of DBS in a model of ataxia by targeting the cerebellum, a major motor center in the brain. We use
Behavior consists of the interaction between an organism and its environment, and is controlled by the brain. Brain activity varies at sub-second time scales, but behavioral measures are usually coarse (often consisting of only binary trial outcomes). To