In medicine, blood type is the classification of red blood cells by the presence of specific substances on their surface. In the early part of the 20th century, physicians discovered that blood transfusions often failed because the blood type of the recipient was not compatible with that of the...
we next performed a cross-tissue meta-analysis of six datasets by additionally including four brain prefrontal cortex (PFC) samples datasets, generated by the ROSMAP2, Mt. Sinai4, London3, and Gasparoni33methylation studies, along with the two blood sample datasets described above...
et al. Sickle blood contains tissue factor-positive microparticles derived from endothelial cells and monocytes. Blood 102, 2678–2683 (2003). Article CAS PubMed Google Scholar Connor, D. E., Exner, T., Ma, D. D. & Joseph, J. E. The majority of circulating platelet-derived microparticle...
Understanding the mechanistic effects of novel immunotherapy agents is critical to improving their successful clinical translation. These effects need to be studied in preclinical models that maintain the heterogenous tumor microenvironment (TME) and dys
Digital health interventions refer to the use of digital technology and connected devices to improve health outcomes and healthcare delivery. This includes
Cardiovascular disease (CVD) is the leading cause of death in the world, with a high incidence and a youth-oriented tendency. RNA modification is ubiquitous and indispensable in cell, maintaining cell homeostasis and function by dynamically regulating ge
There are still several factors to be addressed for the complete clinical application of CRISPR/Cas9 in terms of efficacy and safety, such as the fitness of altered cells, editing efficiency, delivery methods, and potential off-target effects. Edited cells frequently have fitness defects, such as...
Focal cerebral ischemia results from a sudden reduction of cerebral blood flow (CBF) in a specific brain region (Bacigaluppi et al., 2010). The middle cerebral artery occlusion (MCAO) model is a well-known rodent stroke model that produces a cerebral infarction (an area of necrotic tissue) ...
A deep-learning model for transforming the style of tissue images from cryosectioned to formalin-fixed and paraffin-embedded A deep-learning model that transforms cryosectioned whole-slide tissue images into the style of whole-slide formalin-fixed and paraffin-embedded tissue improves the rates of ...
Neutrophil diversity and plasticity underlie the dual potential of TANs in the tumour microenvironment. Myeloid checkpoints as well as the tumour and tissue contexture shape neutrophil function in response to conventional therapies and immunotherapy. We surmise that neutrophils can provide tools to tailor...