The increased need for macromolecular therapeutics, such as peptides, proteins and nucleotides, to reach intracellular targets necessitates more effective delivery vectors and a higher level of understanding of their mechanism of action. Cell penetrating
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Gowhar Ali 1,2,*, Ajmal Khan 3, Sajjad Ahmad 4and Ahmed Al-Harrasi 3,* 1 Department of Pharmacy, University of Peshawar, Peshawar 25120, Pakistan 2 Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA ...
A QSAR model allowed us to deduce that compounds bearing bulky and lipophilic substituents were stronger P-gp inhibitors. Keywords: Tabernaemontana elegans; indole alkaloids; multidrug resistance; P-glycoprotein; ATPase activity; molecular docking; QSAR models Graphical Abstract...
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