The purpose of this research was to develop an intranasal in situ gel based system comprising Topiramate polymeric nanoparticles and evaluate its potential both in vitro and in vivo. Poly (lactic-co-glycolic acid) (PLGA)nanoparticles prepared by nanoprecipitation method were added into the in situ ...
PLGA-PEG-PLGA tri- block copolymers as an in-situ gel forming system for calcitonin delivery. Polym Bull (Heidelberg, Germany) 2007;59:637-46.Ghahremankhani AA, Dorkoosh F, Dinarvand R. PLGA-PEG-PLGA triblock copolymers as an in-situ gel forming system for calcitonin delivery. Polym Bull...
Fig. 3. Swelling and erosion of the PLGA in situ forming implants during the release experiments. (A) Representative Vis images at 525 nm and (B) apparent cross-sectional area changes of the implant in the in vitro gel-based () and the PBS () release testing system at 37 °C. Data ...
A preliminary study exhibited injectability and rapid in vivo gel formation, as well as mechanical stability, cell ingrowth, and ectopic cartilage formation. The injectable PLGA/ALG hydrogels demonstrated attractive properties for future application in a variety of pharmaceutical delivery and tissue ...
Different formulations from Hyaluronic acid (H), Poloxamer (P), Ethoxy-silane-capped poloxamer (PE), and cross-linked Alginate (Alg) were utilized as an in situ gel structure matrix to mirror the mechanical properties of the ECM of CNS. Subsequently, conductivity, surface morphology, size of ...
M. et al. Injectability of a bone filler system based on hydroxyapatite microspheres and a vehicle with in situ gel-forming ability. J. Biomed. Mater. Res. B 87B, 49–58 (2008). CAS Google Scholar Bohner, M. et al. Synthesis of spherical calcium phosphate particles for dental and ...
secreting myo- genic trophic factors and modulating inflammation for reduced fibrosis.82,85 Several studies have been performed to regenerate muscle tissue in situ.86 In one study, an alginate gel-based dual delivery system was used to deliver insulin-like growth factor-1 and VEGF for the enhance...
system, based on stromal cell-derived factor-1 (SDF-1)-encapsulated poly(lactic-co-glycolic acid) (PLGA) microspheres loaded chitosan-gelatin (CS-GEL) composite hydrogel system (SDF-1/CS-GEL@PLGA), with the aim of imparting in situ cell-instructive and osteochondral tissue regenerative ...
(E) The intrinsic mechanism of the PTT/ICB via in situ thermal-responsive aPD-L1/I@LG. (F) The sol-to-gel transition process of the indicated NPs. (G) Temperature-responsive storage of indicated materials. (H) The modulus changes of the LG with three thermal cycles. (I) The ...
Chen Q, Wang C, Zhang X, Chen G, Hu Q, Li H, Wang J, Wen D, Zhang Y, Lu Y, Yang G, Jiang C, Wang J, Dotti G, Gu Z (2019b) In situ sprayed bioresponsive immunotherapeutic gel for post-surgical cancer treatment. Nat Nanotechnol 14(1):89–97 Article CAS PubMed Google Schola...