spatially resolved transcriptomics was heralded as “Method of the Year 2020” by Nature Methods in 2021 [24]. Feasible methods for obtaining a fine-grained assessment of spatial transcriptome can
Radrich K, Tsuruoka Y, Dobson P, Gevorgyan A, Swainston N, Schwartz JM (2010) Reconstruction of an in silico metabolic model of Arabidopsis thaliana through database integration. BMC Syst Biol 4:114Radrich, K., Tsuruoka, Y., Dobson, P., Gevorgyan, A., et al., Reconstruction of an ...
The in silico data described indicate that each of the mutations is capable of altering the structure of PFN-1 in vivo. The potential effect of riluzole and edaravone two FDA approved drugs for ALS, impacting the structural deviations and stabilization of the mutant PFN-1 is evaluated using in...
Video S1. In silico PR nuclear tracking in IMARIS, related to Figure 1 Video S2. Rapid apically directed nuclear translocation, related to Figure 1 Video S3. Basally directed nuclear translocation, related to Figure 1 Video S4. Non-directional nuclear translocation, related to Figure 1 Video ...
Virtual simulation for the prediction of therapeutic targets and agents in silico The expression profile data of human cancer cell lines (CCLs) were downloaded from the CCLE project [38] (https://portals.broadinstitute.org/ccle/). CERES scores, derived from genome-wide CRISPR knockout screenings...
This novel procedure avoids the reconstruction of the aortic arch and the creation of the Damus-Kaye-Stansel (DKS) connection. The antegrade flow originates from a ventricular septal defect (VSD), allowing blood to perfuse the upper circulation (Figure 1). This procedure involves placing a ...
The cellular morphology is represented with a spherical soma and full dendritic reconstruction (axon not shown). Example simulations of EAP signals are shown for a spiny (top: red, cell ID: 395830185) and an aspiny (bottom: blue, cell ID: 469610831) single-cell model. f Four examples of ...
[135]. Ravi et al. applied an in-silico multidimensional model integrating spatially resolved and single-cell gene expression data of 45,615 immune cells from 12 tumor samples and identified that a subset of interleukin-10-releasing HMOX1+ myeloid cells, spatially localized to mesenchymal-like ...
Prediction of novel miRNA biomarker candidates for diagnostic and prognostic analysis of STAD and LIHC: An integratedin silicoapproach Kumkum Kar, Atqiya Fariha, Md Shahadat Hossain, Mahafujul Islam Quadery Tonmoy, ... Md Mizanur Rahaman
Reconstruction of the bilineage trajectory of PDGFRA+PROCR+NPPCs Connective tissue comprised stromal cells with phenotypic and functional complexity,78which provided support during NP development and repair.79We collected 1 372 stromal cells from the NP that were divided into six subclusters (Supplement...