Notes on Sandy Douglas’ article“Sailing in the Thistle Fashion” by Mike Ingham#3969 I particularly like what Sandy says about maintaining speed: “Your object, then, should be to keep your boat going at its best speed all the time.” Optimizing speed is not just about getting up to sp...
point up,[~+up+object]to give greater or added force to (a statement, etc.):to point up the need for caution. Idioms Idiomsbeside the point, not important to, or related to, what is being discussed; irrelevant:Her comments about his money are beside the point. ...
Once activated, these effector CTLs may infiltrate the tumor mass and play a vital role in killing cancer cells, forming what is known as an infiltrated inflamed tumor microenvironment. However, during cancer progression, CTLs may face dysfunction and exhaustion because of immune-related tolerance ...
Sepsis is a mortal response triggered by a severe infection [1]. In the clinic, sepsis is the leading threat to the lives of hospitalized patients and is the primary cause of death in the Intensive Care Unit [2]. As research on sepsis progresses, the understanding of sepsis has evolved fr...
The all-women crew represents the change that is going on in sailing today, according to Bird. “If you were a woman sailor, people didn’t take you very seriously,” she says. “That was in the past. There are a lot of big changes going on now. Women may have to work a lot ha...
3c). Cholera toxin subunit B (CTB) staining, which is commonly used to analyze cholesterol-rich membrane microdomains, revealed reduced cytomembrane cholesterol levels in M2 macrophages compared with those in control cells; however, this was rescued by ABCA1 knockdown (Fig. 3d). Furthermore, in...
Fig. 4. Knockdown Wee1 increased the chemosensitivity in EGFR-TKIs resistant NSCLC cell lines. A, B: MTT assay for H1299-NC and H1299-shRNAs cell lines treated with cisplatin or gemcitabine. C, D: The drug sensitivity of cisplatin or gemcitabine was confirmed by MTT assay in PC9/G2-NC...
Sepsis is a life-threatening disorder disease defined as infection-induced dysregulated immune responses and multiple organ dysfunction. The imbalance between hyperinflammation and immunosuppression is a crucial feature of sepsis immunity. Epigenetic mod
Per2 in the liver functions as a scaffold protein to tether tuberous sclerosis complex 1 (TSC1), Raptor, and mTOR together to specifically sup- press the activity of the mTORC1 complex64. Knockdown of Per2 downregulates autophagy levels while leaving core clock oscillations largely intact65. ...
In 1787, Thomas Lord chose Dorset Square to lay down a cricket ground which, in 1814, moved a mile north to what is now known as Lords Cricket Ground. Dorset Square Hotel is one of the Regency buildings surrounding the tree-filled gardens that would have had a grandstand... more BOOK ...