The primary aim of this review is to analyse all available evidence on the management (surgical and/or conservative) of medication related-osteonecrosis of the jaws (MRONJ) in patients with a history of antiangiogenic drugs therapy and not previously exposed to any antiresorptive drug treatments....
There will be 78 studies that were not chosen to move on to the next stage of the selection process; these are denoted by the letter E1 in the PRISMA model. (i) They are not focusing most of their efforts on the economics of healthcare. For the sake of this investigation, we are ...
1. The human gut microbiome interaction with the immune system in age and disease 2. The gut microbiome and age-related macular degeneration 3. The gut microbiome and retinal artery occlusion 4. The gut microbiome and central serous chorioretinopathy 5. The gut microbiome and inflammatory eye ...
A remarkable aspect in the biology of neoplastic stem cells is plasticity and subclone formation during disease evolution which is relevant clinically as subclone formation is often associated with progression and drug resistance. Recent data suggest that in AML and CML, subclone formation is an early...
Military providers screen for mood, anxiety, and substance use disorders prior to referral to a sleep specialist [109]. The causes for patients presenting with transient or short-term insomnia are more easily identified than patients with chronic insomnia. A service member may experience insomnia at...
To assess the contribution of actin in this process, intracellular parasites expressing MyoJ-3Ty and CEN2-YFP were treated for 4 h with 1 mM of CytD. The diameter of the ring staining of TgMyoJ increased by twofold in treated parasites compared to the untreated ones (Fig. 4g). Moreover,...
Adaptable bioreactor culture system can be used for massive production of multicellular tumor spheroids serving to preclinical drug screening and evaluation. Process sensors can aid the real-time observation and regulation of process parameters, and the microenvironment surrounding the MTSs can be manipulate...
This systematic review discusses gene mutations linked to breast cancer, focusing on signaling pathways that are being targeted with investigational therapeutic strategies, where clinical trials could be potentially initiated in the future are being highlighted. Keywords: Breast, New drug, Chromosome, ...
Population wide effects are often only revealed once a drug is put on the market. Using a collection of hundreds or potentially even thousands of donor cells each with conserved genetic identity, it would be possible to screen for population level effects in an in vitro system. In a library ...
On the other hand with recent progresses in the proteomic methodologies, there is an increasing interest in the application of these novel technologies to improve the drug-discovery process. Because the majority of the drugs act on protein targets, it is important that drug-discovery...