Learn about the 'In Just' poem by E. E. Cummings. Read the background of the poet, find a summary of his poem, study its in-depth analysis, and...
Fig. 3 Variant analysis of patients with rare diseases. PanelAOverview of the filtering steps and the number of variants in rare disease patients referred for WGS analysis (means of 6 patients). The total number of variants in each patient is just above 5 MIO. The analysis begins by eliminat...
Research could also examine how Millennials’ attitudes toward CITs change once they have experience in using CITs in the workplace (rather than just socially), and how older generations’ attitudes toward CITs might change as a result of Millennials’ influence in the workplace. Millennials may ...
Consequently, the protein of interest can be degraded by the cellular proteasome, removing it from the cell rather than just modulating its function. Given their molecular setup as bifunctional molecules, PROTACs are larger than conventional small molecules, which poses potential challenges with respect...
This is due to the fact that the vertical and horizontal tran- sitions require change in the glycosyl conformation of just one of the mismatched adenines, whereas, the diago- nal transitions require the changes in the glycosyl conformations of both the adenines. Interestingly, in the MD ...
[4], particularly those genomes assembled using short-read sequencing technology, as is the case with alligators. In this context, knowledge about satDNAs in crocodilians was limited to just a few works [69,70]. Given that high-throughput satellitome analysis has been very enlightening for ...
To paraphrase EE Cummings, not being dead isn’t the same as being alive. “When you’re dead, they really fix you up. I hope to hell when I do die somebody has sense enough to just dump me in the river or something. Anything except sticking me in a goddam cemetery. People coming...
Joint variant calling—which considers all samples simultaneously—offers several key advantages. First, it produces called genotypes for every sample at all variant positions, not just the ones that were detected in a given individual. This makes it possible to differentiate between a position that ...
the probability of observing their pairing just by chance would be greatly underestimated in the classical matrices and therefore their log-odds score will not reflect a "true" likelyhood ratio. As a consequence of these discrepancies the resulting alignment can be wrong (not pairing together homolog...
Engineering the introduction of foreign genes into the chloroplast genome addresses both of these concerns. Just two copies of transgenes are typically introduced into the nuclear genome, whereas up to 10,000 transgene copies have been engineered into the chloroplast genome of each plant cell, result...