While observational studies and small pilot trials suggest that vitamin D, omega-3 and exercise may slow biological aging, larger clinical trials testing these treatments individually or in combination are lacking. Here, we report the results of a post hoc analysis among 777 participants of the DO...
Vitamin B6 is an essential nutrient with extensive applications in the medicine, food, animal feed, and cosmetics industries. Pyridoxine (PN), the most common commercial form of vitamin B6, is currently chemically synthesized using expensive and toxic ch
In general, preprocessing of NMR metabolomics data involves apodisation, Fourier transform, phasing, baseline correction, and chemical shift calibration [63]. After preprocessing, NMR data are transferred to an NMR spectrum data matrix consisting of chemical shift and peak intensity information [64]. ...
Food proteins can be classified according to nutritional value. Complete proteins contain essential AAs (Fig. 1.1) in the proportion required by the human body, whereas incomplete proteins are those that are deficient in one or more essential AAs. Most proteins of animal origin and some plant pro...
Humic substances (HS) have been widely recognized as a plant growth promoter mainly by changes on root architecture and growth dynamics, which result in increased root size, branching and/or greater density of root hair with larger surface area. Stimulat
A variety of plant protein ingredients (e.g., soybean meal, corn gluten meal, rapeseed meal) and animal byproducts (e.g., meat and bone meal, poultry meal) are being used as alternative protein sources to fish meal in aquafeeds. While these terrestrial, plant-based proteins (e.g., ...
This variability could be associated with a change in the ratio between biosynthesis an degradation of proteins that could bring to a release of amino acids that might serve both as nitrogen and carbon sources. We are aware that the hypothesis is speculative, but the data obtained in this ...
Using stratigraphic analysis of donor-recipient, intensive gene exchanges were observed from Meiothermus species and some unknown sources to Thermus species confirming a well established DNA uptake mechanism as previously proposed. Conclusion Global genome rearrangements were found to play an important role ...
are useful for maximizing the potency of a given inhibitor, but invariably ignore factors critical for understanding drug action, including cell permeability and the potential interaction/inhibition of other proteins in a cellular context.In vivochemical genomic assays address these limitations, and can ...
For certain types of leukaemia, lymphoma and myeloma, the clinical benefits can be profound: for some cancers, more than 50% of recipients achieve complete remission. All of the approved CARs target proteins expressed by antibody-secreting B cells, which are the main driver of many blood ...