2024年2月23日,上海市免疫学研究所叶菱秀课题组在国际免疫学综述类期刊Trends in Immunology在线发表了题为“DNA flexibility can shape the preferential hypermutation of antibody genes”的观点(Opinion)文章。本文系统回顾了抗体超突变(...
Appropriate antimicrobial therapy in the era of multidrug-resistant human pathogens. Clin Microbiol Infect. 2015;21(4):302–12. doi:10.1016/j.cmi.2014.12.025. Article CAS PubMed Google Scholar Martin-Loeches I, Deja M, Koulenti D, Dimopoulos G, Marsh B, Torres A, et al. Potentially ...
The agreement between LRV1 and Leishmania phylogenies corroborates the general hypothesis that LRV1 may have co-evolved with L. Viannia spp9,19,58. While we observed a clear pattern of co-divergence at the parasite species level, we detected a much weaker intraspecific co-phylogenetic signal ...
CXCL8 establishes a concentration gradient from the production site to the blood vessels guiding neutrophils toward the inflammatory site, where they eliminate the pathogens and resolve acute inflammation. Afterwards, CXCL8 may promote angiogenesis by stimulating endothelial cell proliferation and migration ...
H2O2into water and oxygen. On the other hand, in the presence of chloride ions, H2O2is converted to HOCl through myeloperoxidases (MPO) (Reaction (3)), which is highly reactive and plays a vital role in oxidative damage, including the mechanism by which the immune system kills pathogens [...
are largely yet to make their way into routine healthcare. Genotyping arrays have seen slow clinical adoption while whole genome sequencing has had several major applications for the genomic surveillance of microbial pathogens [20], cancer genomics [21] and diagnosis of rare developmental disorders [...
These bacterial taxa co-exist in the samples of animal-environment-worker, suggesting that they may be involved in the transmission of pathogens or the transmission of resistance genes. The differences of dominant taxa in the human could be caused by various factors, such as the delivery and ...
These include cell migration and growth, axonal and neurite outgrowth of polarized cells, axonal local translation, endocytosis, influence of intracellular calcium on PLS3-dependent processes, mechanotransduction, signaling, infection with pathogens and others. This ever-growing knowledge on PLS3 is ...
The innate immune system has the capacity to detect ‘non-self’ molecules derived from pathogens, known as pathogen-associated molecular patterns, via pattern recognition receptors. In addition, an increasing number of endogenous host-derived molecules, termed damage-associated molecular patterns (DAMPs...
A computational method leveraging deep learning and molecular dynamics simulations enables the rapid discovery of antimicrobial peptides with low toxicity and with high potency against diverse Gram-positive and Gram-negative pathogens. Payel Das