Crystal structures of DX9065a and a related bisamidino-aryl inhibitor specific for the blood-clotting factor Xa have been solved in complex with bovine beta-trypsin to a resolution of 1.9 A. Each inhibitor exhibits an extended conformation along the active site, in contrast to the compact folde...
These data indicate that factor Xa has a comparably important role in thrombus formation and extravascular hemostasis, and contrast with previous results in this same animal model in which IXai selectively prevented clotting in the coronary vasculature. 展开 ...
injection of 5 \(\mu\)g oestradiol benzoate EB) was selected based on: a) the oestrous cycle-driven oestrogen’s temporal dynamics; and b) earlier studies showing oestrogen-induced ERα genomic binding and transcription in the mouse brain within this time frame45. Importantly, we also confi...
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The Gla-domainless factor X was then activated by the factor X coagulant protein of Russell's viper venom. Apparent dissociation constants Kd' values for the interaction of factor Va with either factor Xa or Gla-domainless factor Xa were determined kinetically using prothrombin as the substrate....
of the invention is also pharmaceutical compositions containing one or more direct or indirect selective inhibitors of factor Xa which act via antithrombin III in combination with one or more compounds with anti-platelet aggregation activity, and optionally one or more pharmaceutically acceptable vehicles...
adjustment and academic achievement but are also a major factor in mental health problems such as depression, anxiety, and suicidal thoughts [30,31]. Therefore, it is necessary to search for protective factors that can control negative effects of risk factors associated with smartphone addiction ...
For pull-down experiments, the PhBSβ CDS was amplified, cloned into the NdeI and HindIII sites of pET32b expression vector in-frame with a C-terminal 6×His-tag (Novagen, Madison, WI, USA) using ClonExpress II One Step Cloning Kit (Vazyme), and the protein was expressed in E. coli....
This study investigated the safety, pharmacokinetics and pharmacodynamics of multiple oral doses of R1663, a factor Xa inhibitor, and explored the influence of age and gender on pharmacokinetics and pharmacodynamics of R1663. This was a single-blind, randomised, placebo-controlled, dose escalation st...
The former could also be the case for the human transcript that is orthologous with the single mouse transcript, where the second exon might not have been fully processed, as it contains an in frame stop codon that prevents translation of the Kunitz motif. When the sequence of the second ...