Insights into the role of the tumor suppressor pVHL in oxygen sensing motivated the testing of drugs that target the transcription factor HIF or HIF-responsive growth factors, such as VEGF, for the treatment of cancers caused by VHL inactivation, such as
Cytokines produced by immune cells contribute to the development and perpetuation of inflammatory bowel disease (IBD), namely Crohn’s disease and ulcerative colitis, by regulating various aspects of the inflammatory response. Pro-inflammatory cytokines
External WGBS sample information. Additional file 4. Table S3. Tumor vs. normal differences for 4-mer end motifs. Additional file 5. ichorCNA plots for all cfNano and matched Illumina WGS samples. Additional file 6. Review history. Acknowledgements We thank Joshua Moss and Yaping Liu ...
various external stimuli, to be deregulated explicitly in response to TSA or auxin treatment. The strong deregulation of stress-related genes in response to TSA implies the involvement of histone deacetylation in regulating stress responses in plants. Next, we aimed to identify genes of a similar e...
In addition, extracellular IL-33 acts as a sensor for proteolytic activity from external factors or from local innate immune effector cells, thereby harbouring the capacity to dramatically amplify an ongoing immune response. The genetic association studies have shown the presence of multiple discrete ...
This suggests the possibility that although the overall circadian regulation of the lipidome is preserved in both age groups, among older individuals, circadian regulation of the lipidome is differentially susceptible to perturbations induced by external factors such as sleep loss or frequent meals ...
(CCA) represents the 1-cm straight segment, which is located before the bifurcation into its internal and external branches, the internal carotid artery and external carotid artery. The CCA far wall is the easiest segment to be examined and the most commonly used in clinical studies [164]. ...
Evolution of the number of total citation per document and external citation per document (i.e. journal self-citations removed) received by a journal's published documents during the three previous years. External citations are calculated by subtracting the number of self-citations from the total...
https://www.imf.org/external/pubs/ft/issues/issues33/ United States Census Bureau. https://www.census.gov/ Ikegami, N. et al. Japanese universal health coverage: evolution, achievements, and challenges. Lancet 378, 1106–1115 (2011). PubMed Google Scholar Blümel, M. et al. Germany: ...
c, PR curve and F1 score of DeepNeo and other tools in predicting MHC II epitopes derived from external data (n = 812). d, ROC (receiver operating characteristic) curve of DeepNeo and other tools in predicting MHC II epitopes based on the HLA-DRB restricted subset of data used in...