Hyperglycemia is high blood sugar, while hypoglycemia is low blood sugar. Because both can cause major health problems for people with diabetes, it's important
In contrast to normal mice, FOXA1- and FOXA2-deficient mice exhibit hyperglycemia and die shortly after birth [20]. Further studies have shown that FOXA1 and FOXA2 are synergistically involved in regulating Pdx1 (pancreatic and duodenal homeobox 1) expression, affecting pancreatic development [20...
Hyper- and hypoglycemia Most loop and thiazide diuretics are associated with insulin resistance and a dose-related increase in incident diabetes risk [70]. Hyperglycemia theoretically contributes to fall risk because of osmotic diuresis leading to dehydration and neurocognitive symptoms. Insulin resistance ...
Our group has previously shown that acute hypoglycemia leads to PARP-1 overactivation and cell death in adult rats, but not in developing rats (32). Additionally, the animals used in our study were all female. Hormonal differences between genders influence the effects of hyperglycemia (33). ...
Diabetic cardiomyopathy (DCM) is a condition that results from changes in the structure, function, and metabolism of the myocardium and cardiomyocytes in response to diabetes. All these changes that occur during exposure of the heart to chronic hyperglycemia and subsequent oxidative stress will contribu...
Objective The primary objective of this trial was to evaluate the feasibility, safety, and efficacy of a predictive hyperglycemia and hypoglycemia minimization (PHHM) system vs predictive low glucose suspension (PLGS) alone in optimizing overnight glucose control in children 6 to 14 years old. Resea...
Management of hyperglycemia in type 2 diabetes: a patient-centered approach: position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care. 2012;35(6):1364-1379.PubMedGoogle ScholarCrossref Intensive Lifestyle ...
Occurrences of hypoglycemia and hyperglycemia did not differ between groups (eTable 3 in Supplement 2). Discussion Findings of this randomized clinical trial show that 8-hour TRE produced greater weight loss when compared with CR and a control condition. Despite the greater weight loss achieved by...
Maternal Hyperglycemia Causes Hypoglycemia in Male ODM Exposure to maternal hyperglycemia did not alter the birth weights of surviving males (OCM 7.1 ± 0.7 g, n = 63; ODM 6.9 ± 0.9 g, n = 54) or females (OCM 6.7 ± 0.7 g, n = 64; ODM 6.6 ± 0...
Conclusion: Hyperglycemia accentuated hypoglycemia- induced neuronal injury, likely via PARP-1 overactivation. Although BDNF was upregulated, it was not neuroprotective and potentially exaggerated injury by binding to p75NTR recep- tor. Conversely, ketonemia during hypoglycemia attenuated neuronal injury. ...