As an internal reference gene, in addition to having stable expression levels in different samples, it should also show a low mutation rate and as few transcripts and pseudogenes as possible [43]. However, the GAPDH gene has 11 transcripts, but only 2 of them encode functional canonical ...
With these being said, we recognised limitations of Ca imaging: firstly, due to the sensitivity issue, neurons with little or no spiking activity, or highly active but showing little firing rate change (e.g. some Subtype I SST neurons), or having strong Ca buffering capacity (e.g. PV neu...
Maternal nutrition during pregnancy can induce epigenetic alterations in the fetal genome, such as changes in DNA methylation. It remains unclear whether these epigenetic alterations due to changes in maternal nutrition are transitory or persist over tim
This reduces 26S proteasome activity, leading to impaired cell proliferation while inducing apoptotic cell death and reducing tumor growth. In addition, in-vivo analysis in immunocompromised mice having breast cancer revealed that curcumin treatment significantly reduces its tumor burden (Banerjee et al....
The increasing availability of large-scale protein-protein interaction data has made it possible to understand the basic components and organization of cell machinery from the network level. The arising challenge is how to analyze such complex interactin
Physical activity was assessed by total physical activities from occupational, transportation, housework, and leisure time according to the International Physical Activity Questionnaire,18 and categorized into low (<600 metabolic equivalent of task [MET]–min/wk; eg, having 3 days of walking for 30 ...
10.1073/pnas.0805411105. Article PubMed Central CAS PubMed Google Scholar Combs SE, Krieglstein K, Unsicker K: Reduction of endogenous TGF-beta increases proliferation of developing adrenal chromaffin cells in vivo. J Neurosci Res. 2000, 59 (3): 379-383. 10.1002/(SICI)1097-4547(20000201)59...
In addition to demonstrating that the relaxation activity of wild-type MtTOP1 was functional in E. coli, we also showed that when a mutant version of MtTOP1, with the G116 S TOPRIM mutation that inhibits DNA religation [6] was overexpressed in E. coli, the SOS response is induced ...
Understanding polyphenism, the ability of a single genome to express multiple morphologically and behaviourally distinct phenotypes, is an important goal for evolutionary and developmental biology. Polyphenism has been key to the evolution of the Hymenop
This may attribute to patients with lowest pretreatment PLC (Q1) having a poor outcome in our study. Although the cut off criteria are slightly different for each study, patients with pre-treatment lymphocyte count less than 1000/mm3 or 1500/mm3 showed a poor prognosis than those patients who...