We screened a small-molecule library of diverse compounds for selective inhibitors of KIF18A MT-ATPase motor activity. Two compound hits were discovered that phenocopied the effects of KIF18A KD in cells; these hits are structurally distinct from the KIF18A inhibitor BTB-1 (refs. 27,28). Next...
The ionic-current change owing to a translocation event reflects the size, shape and charge of the molecule5. There are two types of nanopore: biological and solid-state. Although biologically derived protein nanopores are ideally suited for DNA sequencing6, solid-state nanopores offer control over...
SB505124, a small molecule inhibitor of TGF-β receptor I (ALK5), was examined in this context. We observed that BC patients in the low NAC risk group exhibited significantly lower IC50 values for SB505124 compared to those in the high NAC risk group. This suggests that patients in the...
Oxidatively damaged DNA bases are substrates for two overlapping repair pathways: DNA glycosylase-initiated base excision repair (BER) and apurinic/apyrimidinic (AP) endonuclease-initiated nucleotide incision repair (NIR). In the BER pathway, an AP endonuclease cleaves DNA at AP sites and 3′-bloc...
mandshurica, the jasmonic acid biosynthetic process, jasmonic acid metabolic process, carboxylic acid metabolic process, small molecule metabolic process, and cellular lipid metabolic process were the top five BPs subgroups, while the microbody and peroxisome were the top two CC subgroups. The top ...
This molecule had low molecular weight and topological polar surface area but no active efflux [111]. Likewise, SPH3643 a novel orally active small CDK4/6i effectively penetrated the murine cerebrum and significantly decreased GBM growth [104]. In 2014, the multikinase inhibitor ON123300 was ...
Tens of short smFISH probes are designed for one RNA, which allows sensitive detection of a single RNA molecule. Recently, a FISH method with branched DNA (bDNA) amplification was also described in plants [5]. Despite these advances, most existing RNA FISH methods still require sectioning of ...
Inactivated Sendai virus particle upregulates cancer cell expression of intercellular adhesion molecule-1 and enhances natural killer cell sensitivity on cancer cells. Cancer Sci, 2017; 108, 2333-41. doi: 10.1111/cas.2017.108.issue-12 [8] Fujihara A, Kurooka M, Miki T, et al. Intratumoral ...
where thexis the alternative allele depth for a certain variant;nis the total sequencing depth for a certain variant;αis the effective alternative allele DNA molecule count for a certain variant and sample before PCR;βis the effective reference allele DNA molecule count for a certain variant an...
Physiologically Relevant, Humanized Intestinal Systems to Study Metabolism and Transport of Small Molecule Therapeutics. Drug Metab. Dispos. 2018, 46, 1581–1587. [Google Scholar] [CrossRef] Disclaimer/Publisher’s Note: The statements, opinions and data contained in all publications are solely those...