DNA origami-based nanorobot presents thrombin to cause tumor infarction after specific recognition of a tumor vessel marker. Nanoscale robots have potential as intelligent drug delivery systems that respond to molecular triggers1,2,3,4. Using DNA origami
Certain strains of Escherichia coli produce colibactin, a small-molecule genotoxin that can adduct to DNA and induce double-strand DNA breaks8. In humans, about a dozen metagenomic studies on various populations across the world have identified substantial changes in abundance of specific bacteria9,...
Christian T. Farrar Article11 Nov 2021Nature Biomedical Engineering Ultrasensitive detection of circulating tumour DNA via deep methylation sequencing aided by machine learning Deep methylation sequencing aided by a machine-learning classifier of methylation patterns enables the detection of early cancers from...
A survey of the sorghum transcriptome using single-molecule long reads. Nat Commun. 2016;7:11706. CAS PubMed PubMed Central Google Scholar Ali N, Heslop-Harrison JSP, Ahmad H, Graybosch RA, Hein GL, Schwarzacher T. Introgression of chromosome segments from multiple alien species in wheat ...
SB505124, a small molecule inhibitor of TGF-β receptor I (ALK5), was examined in this context. We observed that BC patients in the low NAC risk group exhibited significantly lower IC50 values for SB505124 compared to those in the high NAC risk group. This suggests that patients in the...
The molecule is identical to vorinostat (2) except for substitution of the phenyl ring to incorporate an ester group for selective targeting. The ester undergoes hydrolysis in cells expressing carboxylesterase-1 (hCE-1), namely hepatocytes and monocytes. In normal cells, uptake of the neutral drug...
Mucosal addressin cell adhesion molecule 1 ELISA Kit的详细说明书 检测范围:0.312-20 ng/mL 使用:本试剂仅供科研使用 保存:2-8℃ 有效期:6个月 检测方法:ELISA 产品性状:96T/48T,盒装液体 贮藏条件:2-8°C 产品主要成分:酶标板,试剂,标准品等。
J Med Chem. 2024 Feb 22;67(4):2631-2666.[4] Rooney L, Jones C. Recent Advances in ALK2 Inhibitors. ACS Omega. 2021 Aug 6;6(32):20729-20734.[5] Katagiri T, et al. Accumulated Knowledge of Activin Receptor-Like Kinase 2 (ALK2)/Activin A Receptor, Type 1 (ACVR1) as a Target...
we show how to transduce small-molecule ligands in a dose-dependent fashion into gene expression in mammalian cells using two-component signaling machinery. First, we engineer mutually complementing truncated mutants of a histidine kinase unable to dimerize and phosphorylate the response regulator. Next...
the t Fig. 1: High eccDNA load inArabidopsis thalianaepigenetic mutants is associated with new TE insertions in the genome. aScheme depicting the experimental design: from Arabidopsis plants both linear and circular DNA were extracted and sequenced using Illumina and Nanopore (ONT) platforms in ...