Cell Replication: Transcription and translation are important functions of the cell. Transcription is a function of RNA as it makes copies of the DNA units of adenine, thymine, guanine, cytosine, and uracil. Cel
Where in human cells does each of these processes occur? Where does transcription take place in a eukaryotic cell? Where does the process of translation in protein synthesis in the human cell occur? Where in the cell is mRNA translated into proteins? What is the product of transcription? Where...
This Review discusses the major advances and changes made over the past 3 years to our understanding of chimeric antigen receptor (CAR) T cell efficacy and safety. Recently, the field has gained insight into how various molecular modules of the CAR in
Single cell transcriptomic analysis of HPV16-infected epithelium identifies a keratinocyte subpopulation implicated in cancer Mary C. Bedard, Tafadzwa Chihanga, Adrean Carlile, Robert Jackson, Marion G. Brusadelli, Denis Lee, Andrew VonHandorf, Mark Rochman, Phillip J. Dexheimer, Jeffre...
This review provides a comprehensive atlas of QTLs, genes, and alleles conferring resistance to 28 important diseases in all major soybean production regions in the world. Abstract Breeding disease-resistant soybean [Glycine max (L.) Merr.] varieties is a common goal for soybean breeding programs ...
Ferroptosis is a novel type of cell death with distinct properties and recognizing functions involved in physical conditions or various diseases including cancers. The fast-growing studies of ferroptosis in cancer have boosted a perspective for its usage
cell–cell junctions and disruption of barrier function in in vitro BBB model. In mice, intra-arterial injection of 3 μM melittin resulted in robust and reversible BBB opening. Of note, injection of 5 μM peptide led to neurological deficits indicating a narrow therapeutic window [75]. ...
When there is no lactose in the cell, a protein called the lac repressor binds to the operator. The repressor protein physically prevents RNA polymerase from attaching to the promoter. This kind of regulation is called negative regulation, because transcription is prevented after a protein binds ...
Apn1 can be targeted to the mitochondria through a particular mechanism mediated by Pir1, a yeast cell wall protein with internal repeats (Pir) [67]. Pir1 has the ability to compete with the nuclear import factors for binding to the nuclear localization sequence, allowing part of Apn1 to ...
which competitively binds to IL-2 to increase Foxp3 transcription and inhibit Treg cell apoptosis and effector T cell proliferation. Tregs can also secrete IL-10 and TGF-β to inhibit the function of immunocompetent cells such as DCs, macrophages, mastocytes, Th1/Th2 cells, cytotoxic T cells...